Title text: Could be worse. The last guy in that situation fell for one of the transient trumpeting angels.
In the first panel, Cueball proposes to a woman. While he does this, a narrator (most likely the man's inner voice) explains why he wants to marry her. He says that he realizes that is no choir of trumpeting angels when you meet the right girl. And that one must overcome his fears and doubts to realize that the woman he's with is perfect for him, and that she is 'the one'.
In the second panel, they get married. And in the third panel, after they are married, Megan comes in saying 'Hi'. And the Cueball has the full 'love at first sight'-experience. He sees a choir of angels, and they are trumpeting and all. She is definitely the 'one' he was looking for all the time.
So he realizes that his theory he had when he got married, is false. And that his true love is standing in front of him, and is not the one he married. A difficult situation, he doesn't know how to react or what to do at all. And this is expressed by him just thinking in his head 'Well, shit.' (what now?).
The title text notes that the last time someone had this (probably another guy), the guy fell in love with one of the angels. Which is of course even worse, because they are transient, and the only way to see them again is by meeting the perfect 'girl'. But if this girl is one of the trumpeting angels, this leads to a sort of paradox. Thus the guy can never see his true love again.
- [Cueball proposing to a girl on his knee.]
- I understand now. There's no choir of angels when you meet the right person. It's about growing out of your fears to realize what you have is what you want.
- [Cueball and the woman getting married.]
- Cueball: I do.
- Girl: I do.
- [A cloud with trumpeting angels appears over Megan.]
- Megan: Hi.
- Well, shit.