explain xkcd - User contributions [en]

3106: Farads

2025-06-25T04:49:13Z

Grandfatherclock: remove extra line feed

{{comic
| number = 3106
| date = June 23, 2025
| title = Farads
| image = farads_2x.png
| imagesize = 677x253px
| noexpand = true
| titletext = 'This HAZMAT container contains radioactive material with activity of one becquerel.' 'So, like, a single banana slice?'
}}

==Explanation==
{{incomplete|This page was created recently by one Katal. Don't remove this notice too soon.}}
This comic shows Cueball showing off several items that (he claims to) compose approximately one of a given unit, with Megan and White Hat reacting appropriately. The first three - meters, pounds, and volts - are all very common units that everyday people will regularly encounter, and so receive minimal reaction.

Most household batteries are around 1.5V, although 1V batteries do exist. As a battery is discharged, the outputted voltage slowly decreases. Since one volt is below what most batteries market themselves as, the battery could be close to being completely drained and should be recharged. If the battery is supposed to operate at higher voltages, it might indicate that the battery had suffered a deep discharge. In this case, the battery may have suffered permanent damage to its capacity to charge and special care should be taken to safely recharge it.

However, 1 {{w|Farad|farad}} is really goddamn big. In common use, even millifarads are quite large, and most consumer electronics use at most a nanofarad. A 1-farad capacitor is considered a supercapacitor. Cueball claiming to have a 1-farad capacitor elicits ''panic'' from Megan and White Hat, who not-unreasonably ask why the hell he's carrying it around and brandishing it in front of them.

The title text resumes more ordinary units, albeit on a less common topic. A becquerel amounts to one radioactive decay per second on the atomic level, which is a really low level of radioactivity. As observed, the material in question could be a single ''slice'' of a banana (primarily due to the decay of the trace of potassium-40 in the total potassium it contains). Hence, it is both impractical and unnecessary to contain it inside a HAZMAT container unless the material is dangerous for other reasons (such as corrosiveness or flammability). In comparison, the human body itself [https://web.archive.org/web/20200220103556/https://radioactivity.eu.com/site/pages/Activity_Doses.htm has an activity of 8000 bq.]

Capacitance (C) is the ratio between charge (coulombs or amp-seconds) and electromotive force (V, volts or joules per coulomb). Weight (pounds or newtons) is the ratio between gravitational potential energy (joules) and height (meters). The stone weighs 1 pound or 4.45 newtons. If the 1 farad capacitor is charged to 1 volt, it will hold 1/2 C V^2 or 1/2 joule. If its discharge is used to raise the 4.45 newton stone, it will throw the stone 1/8.9 m or about 11 centimeters. This is a hammer blow.

A 1 farad capacitor charged by 9-volt battery will throw the stone 10 meters high, a sledgehammer blow. To prevent static electricity from building lethal charge, unused supercapacitors are usually stored and transported with "keeper", a steel or aluminum bar shorting the terminals. A 0.1 farad capacitor intermittently shorted with a screwdriver makes "lightning flashes" that will illuminate a theater.

==Transcript==
{{incomplete transcript|Don't remove this notice too soon.}}
: [Cueball holds a stick while talking with Megan and White Hat]
: Cueball: This stick is one meter long.
: Megan: Cool.
: White Hat: That's a nice stick.
:
: [Cueball holds a smallish rock]
: Cueball: This rock weighs one pound.
: Megan: I'd believe it.
: White Hat: Looks like a normal rock.
:
: [Cueball holds a small battery]
: Cueball: This battery is one volt.
: Megan: Seems fine.
: White Hat: Might need a recharge.
:
: [Cueball holds a capacitor while Megan and White Hat panic]
: Cueball: This capacitor is one farad.
: Megan: Aaaaa! Be careful!!
: White Hat: Put it down!!

{{comic discussion}}<noinclude>

3106: Farads

2025-06-25T04:46:53Z

Grandfatherclock: Added practical description of farad magnitude in terms of stick, stone, and battery.

{{comic
| number = 3106
| date = June 24, 2025
| title = Farads
| image = farads_2x.png
| imagesize = 677x253px
| noexpand = true
| titletext = 'This HAZMAT container contains radioactive material with activity of one becquerel.' 'So, like, a single banana slice?'
}}

==Explanation==
{{incomplete|This page was created recently by one Katal. Don't remove this notice too soon.}}
This comic shows Cueball showing off several items that (he claims to) compose approximately one of a given unit, with Megan and White Hat reacting appropriately. The first three - meters, pounds, and volts - are all very common units that everyday people will regularly encounter, and so receive minimal reaction.

Most household batteries are around 1.5V, although 1V batteries do exist. As a battery is discharged, the outputted voltage slowly decreases. Since one volt is below what most batteries market themselves as, the battery could be close to being completely drained and should be recharged. If the battery is supposed to operate at higher voltages, it might indicate that the battery had suffered a deep discharge. In this case, the battery may have suffered permanent damage to its capacity to charge and special care should be taken to safely recharge it.

However, 1 {{w|Farad|farad}} is really goddamn big. In common use, even millifarads are quite large, and most consumer electronics use at most a nanofarad. A 1-farad capacitor is considered a supercapacitor. Cueball claiming to have a 1-farad capacitor elicits ''panic'' from Megan and White Hat, who not-unreasonably ask why the hell he's carrying it around and brandishing it in front of them.

The title text resumes more ordinary units, albeit on a less common topic. A becquerel amounts to one radioactive decay per second on the atomic level, which is a really low level of radioactivity. As observed, the material in question could be a single ''slice'' of a banana (primarily due to the decay of the trace of potassium-40 in the total potassium it contains). Hence, it is both impractical and unnecessary to contain it inside a HAZMAT container unless the material is dangerous for other reasons (such as corrosiveness or flammability). In comparison, the human body itself [https://web.archive.org/web/20200220103556/https://radioactivity.eu.com/site/pages/Activity_Doses.htm has an activity of 8000 bq.]

Capacitance (C) is the ratio between charge (coulombs or amp-seconds) and electromotive force (V, volts or joules per coulomb). Weight (pounds or newtons) is the ratio between gravitational potential energy (joules) and height (meters). The stone weighs 1 pound or 4.45 newtons. If the 1 farad capacitor is charged to 1 volt, it will hold 1/2 C V^2 or 1/2 joule. If its discharge is used to raise the 4.45 newton stone, it will throw the stone 1/8.9 m or about 11 centimeters. This is a hammer blow.

A 1 farad capacitor charged by 9-volt battery will throw the stone 10 meters high, a sledgehammer blow. To prevent static electricity from building lethal charge, unused supercapacitors are usually stored and transported with "keeper", a steel or aluminum bar shorting the terminals. A 0.1 farad capacitor intermittently shorted with a screwdriver makes "lightning flashes" that will illuminate a theater.

==Transcript==
{{incomplete transcript|Don't remove this notice too soon.}}
: [Cueball holds a stick while talking with Megan and White Hat]
: Cueball: This stick is one meter long.
: Megan: Cool.
: White Hat: That's a nice stick.
:
: [Cueball holds a smallish rock]
: Cueball: This rock weighs one pound.
: Megan: I'd believe it.
: White Hat: Looks like a normal rock.
:
: [Cueball holds a small battery]
: Cueball: This battery is one volt.
: Megan: Seems fine.
: White Hat: Might need a recharge.
:
: [Cueball holds a capacitor while Megan and White Hat panic]
: Cueball: This capacitor is one farad.
: Megan: Aaaaa! Be careful!!
: White Hat: Put it down!!

{{comic discussion}}<noinclude>

2943: Unsolved Chemistry Problems

2024-06-09T19:54:00Z

Grandfatherclock:

{{comic
| number = 2943
| date = June 7, 2024
| title = Unsolved Chemistry Problems
| image = unsolved_chemistry_problems_2x.png
| imagesize = 361x386px
| noexpand = true
| titletext = I'm an H⁺ denier, in that I refuse to consider loose protons to be real hydrogen, so I personally believe it stands for 'pretend'.
}}

==Explanation==
{{incomplete|Created by a caffeinated biochemist - Please change this comment when editing this page. Do NOT delete this tag too soon.}}

There is a list of mathematical problems that are yet to be solved (such as P=NP). This comic makes a spin on it, by stating that there are (as of yet) unsolved chemistry problems. The scientist at what is apparently the "grand opening" of a new chemistry lab lists several real chemistry problems, followed by one also-unsolved-but-less-scientific problem (the p in pH)

'''Arbitrary Enzyme Design:'''

{{w|Enzymes}} are catalytic proteins. Enzyme catalysis is often unique in comparison with other catalysis methods as it is highly specific, or tailored to a specific reaction. As such, enzyme catalysis, besides being the basis of all biochemical processes, is becoming increasing relevant to industrial synthesis processes. As enzymes can be easily synthetically produced through recombinant gene technology, being able to design an arbitrary enzyme for any reaction means that effectively any reaction can be relatively easily catalyzed, revolutionizing the chemical synthesis industry.

'''Protein Folding:'''

{{w|Protein|Proteins}} are large molecules that consist of chains of amino acids. These amino acids chains become {{w|Protein Folding|folded}} in extremely complex ways into intricate 3D structures, and the way a protein is folded is of critical importance to its function. Because of the huge importance of proteins to biological life, biologists have devoted significant attention over many decades to the problem of {{w|Protein structure prediction|protein structure prediction}}. This refers to the ability to predict the 3D structure of a protein based on the amino acid sequence, and remains one of the most important problems in computational biology. The ability to predict protein structure purely from amino acid sequence, the so-called "de novo" prediction, is known in computational biology as an unusually difficult problem due to the complexity of amino acid chains. Known as "Levinthal's paradox," the number of possible conformations from the backbone conformations alone is estimated to have in the ballpark of 10^300 different conformations. Despite this, protein folding occurs extremely quickly in reality. Because of this difficulty in sampling conformations, even with optimization, such as secondary structure prediction and Monte Carlo simulation, a "true" accurate simulation is extremely computationally expensive. Because of this, the most accurate solutions, such as AlphaFold, utilize a combination of homology modeling - sampling experimentally determined proteins with similar sequences to infer structural motifs and similarities - and deep learning to accurately guess protein structure.

'''Depolymerization:'''

Polymers are very large molecules formed out of repeating subunits called monomers. Monomers are molecules, typically organic in nature, that can bond with at least 2 other molecules, making long chains or networks. That process is known as polymerization. Depolymerization is breaking down polymers into the small molecules they were originally made from. This is done through a variety of processes such as using radiation, electrolysis, adding chemicals, and other means. Plastics are the best-known polymers, but cellulose, proteins, and DNA are also technically polymers. The huge number of varieties and mixtures in plastics makes recycling them a huge challenge, and there is increasing concern about plastic waste damaging the environment.

Polymerization is usually exothermic, releasing energy as heat. To reverse this would require adding energy, in a targeted way. Simply ''destroying'' a polymer, by means of highly-reactive chemicals, heat, or radiation, doesn't generally release the monomer molecules to a significant degree; most of the reaction products are highly degraded. Most polymers are made by a process of catalysis, with the small monomer molecules interacting via a catalyst structure, often in liquid form, and the eventual product is usually solid. To reverse this would require getting the catalyst to interact in a very precise way with the solid polymer, and it's relatively difficult for the catalyst structure to get into the proper configuration with the solid tangled polymer molecules.

Another highly-desired depolymerization process would be to convert cellulose into its component glucose molecules. That glucose could then be used for a variety of different purposes, including fermentation to alcohol to use as a fuel. Currently, when plants are grown, much of the solar energy and carbon dioxide they absorb ends up in the form of cellulose rather than as starch, sugar, protein, or other substances that we find useful. Our being able to make use of the cellulose would make farming much more energy-efficient. Some organisms are able to depolymerize cellulose by means of enzymes, but our ability to use similar processes on an industrial scale is still limited. (Those organisms use a complex multi-step biochemical process which essentially "invests" energy into splitting off a glucose molecule, then recoups the investment by metabolizing the glucose.) It's also possible to depolymerize cellulose at high temperature and pressure using nothing more than water and acid, but that process is energy-intensive. It ''might'' be possible to do it with a solar-heated reactor.

'''What the “p” in pH stands for:'''

“p” shows up in pH, pKa, pKb, and other things related to the concentration of H+ ions and OH- ions. The meaning of the "p" in "pH" has been the subject of much dispute. It is sometimes referred to as "power of Hydrogen", but it's not at all clear in English what this means - are we talking about hydrogen fuel cells, or someone's superpower? The connection - which most teachers (original research) do not make - is that this "power" should be understood in the sense of "x to the third power." pH is a logarithmic scale, and the logarithm is the inverse of the exponent, and, in all three languages that pH was first published in, the word for "potency" is used for exponents. The term pH was introduced by {{w|Søren Peter Lauritz Sørensen|Søren Peter Lauritz Sørensen}}, who did not publish his results in English, and more accurately translates as "hydric exponent". The letter p could stand for,in the languages in which Sørensen published: the French 'puissance' , German Potenz, or Danish potens, all referring to the concept of the "exponent" in exponential functions.

'''ρ operator'''

2000 years ago, Romans knew nothing of zero, place-value-notation, nor real numbers. Roman scribes knew integers, integer ratios, and standard oft-used ratios. In modern times, we buy and sell by the pair (pr), dozen (dz), and score (sc). Roman shipping used ρ and ρρ to represent 4/5 and 5/8 sizes. As [https://en.wikipedia.org/wiki/Greek_numerals Ionian numerals] gave way to decimal point use, ρ use became archaic, remaining only in a few fields like music, art, and chemistry.

Over centuries, ρ gradually evolved into a real number operator as log base cube root of 1/2 (musical minor third), square root of golden ratio (artistic fractal shape), tenth root of 1/10 (statistical power of effect), or 1/10 (chemical strength). Lacking otherwise infrequently-used greek letter ρ printers began using latin p instead.

'''Title Text: Hydrogen Denier'''

In the title text, Randall claims to be an H+ denier by refusing to consider loose protons to be hydrogen atoms, and as such, the “p” stands for pretend. Part of the joke is Randall's implication that this is a well-known conspiracy theory that he personally buys into (it isn't). The word "denier" is often used as shorthand for other conspiracy theories, such as a "climate change denier" or a "moon landing denier."

Here's a breakdown of this joke:

* H+ is the chemical symbol for a positively-charged atom of hydrogen, the smallest atom on the Periodic Table. Since hydrogen is normally just one proton and one electron, when you take the electron away, you make it positively charged (the + sign in the superscript) and you effecitvely end up with just a single loose proton. So the shorthand for "loose proton" is to refer to it as an H+ ion.

* pH is taught in high school science class to essentially measure the concentration of extra loose protons in, say, an aquarium. (Different fish prefer slightly different pH levels/alkilinity.) As mentioned earlier, you can interpret the term "pH" to be referring to the "p" of "H" -- the power/potency of H+ ions.

(Note that in reality, lone H+ ions do not exist in water, and instead they glom onto H2O molecules to form H3O+ and H5O2+/(H2O--H--OH2)+. If you don't know what these chemical symbols mean, don't worry about it.)

But as an H+ denier, Randall doesn't consider loose protons to be hydrogen atoms. He has a purist's view of hydrogen, that it is just "pretending" to be hydrogen as soon as it loses an electron. As a denier, he interprets the term "pH" as referring to the concentration of "pretend Hyodrgen."

==Transcript==
:[Hairbun stands behind a lectern on a podium speaking into a microphone on the lectern. A Cueball like guy stands to the left and another Cueball like guy and Megan stand to the right. There is a large sign hanging in the background along with some ornaments.]
:Sign: Grand Opening
:Hairbun: Our lab will be working on chemistry's top unsolved problems: arbitrary enzyme design, protein folding, depolymerization, and, of course, the biggest one of all:
:Hairbun: ''Figuring out what the "p" in "pH" stands for.''

{{comic discussion}}

[[Category:Comics featuring Hairbun]]
[[Category:Comics featuring Cueball]]
[[Category:Comics featuring Megan]]
[[Category:Multiple Cueballs]]
[[Category:Chemistry]]

2943: Unsolved Chemistry Problems

2024-06-09T19:24:07Z

Grandfatherclock:

{{comic
| number = 2943
| date = June 7, 2024
| title = Unsolved Chemistry Problems
| image = unsolved_chemistry_problems_2x.png
| imagesize = 361x386px
| noexpand = true
| titletext = I'm an H⁺ denier, in that I refuse to consider loose protons to be real hydrogen, so I personally believe it stands for 'pretend'.
}}

==Explanation==
{{incomplete|Created by a caffeinated biochemist - Please change this comment when editing this page. Do NOT delete this tag too soon.}}

There is a list of mathematical problems that are yet to be solved (such as P=NP). This comic makes a spin on it, by stating that there are (as of yet) unsolved chemistry problems. The scientist at what is apparently the "grand opening" of a new chemistry lab lists several real chemistry problems, followed by one also-unsolved-but-less-scientific problem (the p in pH)

'''Arbitrary Enzyme Design:'''

{{w|Enzymes}} are catalytic proteins. Enzyme catalysis is often unique in comparison with other catalysis methods as it is highly specific, or tailored to a specific reaction. As such, enzyme catalysis, besides being the basis of all biochemical processes, is becoming increasing relevant to industrial synthesis processes. As enzymes can be easily synthetically produced through recombinant gene technology, being able to design an arbitrary enzyme for any reaction means that effectively any reaction can be relatively easily catalyzed, revolutionizing the chemical synthesis industry.

'''Protein Folding:'''

{{w|Protein|Proteins}} are large molecules that consist of chains of amino acids. These amino acids chains become {{w|Protein Folding|folded}} in extremely complex ways into intricate 3D structures, and the way a protein is folded is of critical importance to its function. Because of the huge importance of proteins to biological life, biologists have devoted significant attention over many decades to the problem of {{w|Protein structure prediction|protein structure prediction}}. This refers to the ability to predict the 3D structure of a protein based on the amino acid sequence, and remains one of the most important problems in computational biology. The ability to predict protein structure purely from amino acid sequence, the so-called "de novo" prediction, is known in computational biology as an unusually difficult problem due to the complexity of amino acid chains. Known as "Levinthal's paradox," the number of possible conformations from the backbone conformations alone is estimated to have in the ballpark of 10^300 different conformations. Despite this, protein folding occurs extremely quickly in reality. Because of this difficulty in sampling conformations, even with optimization, such as secondary structure prediction and Monte Carlo simulation, a "true" accurate simulation is extremely computationally expensive. Because of this, the most accurate solutions, such as AlphaFold, utilize a combination of homology modeling - sampling experimentally determined proteins with similar sequences to infer structural motifs and similarities - and deep learning to accurately guess protein structure.

'''Depolymerization:'''

Polymers are very large molecules formed out of repeating subunits called monomers. Monomers are molecules, typically organic in nature, that can bond with at least 2 other molecules, making long chains or networks. That process is known as polymerization. Depolymerization is breaking down polymers into the small molecules they were originally made from. This is done through a variety of processes such as using radiation, electrolysis, adding chemicals, and other means. Plastics are the best-known polymers, but cellulose, proteins, and DNA are also technically polymers. The huge number of varieties and mixtures in plastics makes recycling them a huge challenge, and there is increasing concern about plastic waste damaging the environment.

Polymerization is usually exothermic, releasing energy as heat. To reverse this would require adding energy, in a targeted way. Simply ''destroying'' a polymer, by means of highly-reactive chemicals, heat, or radiation, doesn't generally release the monomer molecules to a significant degree; most of the reaction products are highly degraded. Most polymers are made by a process of catalysis, with the small monomer molecules interacting via a catalyst structure, often in liquid form, and the eventual product is usually solid. To reverse this would require getting the catalyst to interact in a very precise way with the solid polymer, and it's relatively difficult for the catalyst structure to get into the proper configuration with the solid tangled polymer molecules.

Another highly-desired depolymerization process would be to convert cellulose into its component glucose molecules. That glucose could then be used for a variety of different purposes, including fermentation to alcohol to use as a fuel. Currently, when plants are grown, much of the solar energy and carbon dioxide they absorb ends up in the form of cellulose rather than as starch, sugar, protein, or other substances that we find useful. Our being able to make use of the cellulose would make farming much more energy-efficient. Some organisms are able to depolymerize cellulose by means of enzymes, but our ability to use similar processes on an industrial scale is still limited. (Those organisms use a complex multi-step biochemical process which essentially "invests" energy into splitting off a glucose molecule, then recoups the investment by metabolizing the glucose.) It's also possible to depolymerize cellulose at high temperature and pressure using nothing more than water and acid, but that process is energy-intensive. It ''might'' be possible to do it with a solar-heated reactor.

'''What the “p” in pH stands for:'''

“p” shows up in pH, pKa, pKb, and other things related to the concentration of H+ ions and OH- ions. The meaning of the "p" in "pH" has been the subject of much dispute. It is sometimes referred to as "power of Hydrogen", but it's not at all clear in English what this means - are we talking about hydrogen fuel cells, or someone's superpower? The connection - which most teachers (original research) do not make - is that this "power" should be understood in the sense of "x to the third power." pH is a logarithmic scale, and the logarithm is the inverse of the exponent, and, in all three languages that pH was first published in, the word for "potency" is used for exponents. The term pH was introduced by {{w|Søren Peter Lauritz Sørensen|Søren Peter Lauritz Sørensen}}, who did not publish his results in English, and more accurately translates as "hydric exponent". The letter p could stand for,in the languages in which Sørensen published: the French 'puissance' , German Potenz, or Danish potens, all referring to the concept of the "exponent" in exponential functions.

'''ρ operator'''

2000 years ago, Romans knew nothing of zero, place-value-notation, nor real numbers. Roman scribes knew integers, integer ratios, and standard oft-used ratios. In modern times, we buy and sell by the pair (pr), dozen (dz), and score (sc). Roman shipping used ρ and ρρ to represent 4/5 and 5/8 sizes. As [https://en.wikipedia.org/wiki/Greek_numerals Ionian numerals] gave way to decimal point use, ρ use became archaic, remaining only in a few fields like music, art, and chemistry.

Over centuries, ρ gradually evolved into a real number operator as log base cube root of 1/2 (musical minor third), square root of golden ratio, tenth root of 1/10 (statistical power of effect), or 1/10 (chemical strength). Lacking otherwise infrequently-used greek letter ρ printers began using latin p instead.

'''Title Text: Hydrogen Denier'''

In the title text, Randall claims to be an H+ denier by refusing to consider loose protons to be hydrogen atoms, and as such, the “p” stands for pretend. Part of the joke is Randall's implication that this is a well-known conspiracy theory that he personally buys into (it isn't). The word "denier" is often used as shorthand for other conspiracy theories, such as a "climate change denier" or a "moon landing denier."

Here's a breakdown of this joke:

* H+ is the chemical symbol for a positively-charged atom of hydrogen, the smallest atom on the Periodic Table. Since hydrogen is normally just one proton and one electron, when you take the electron away, you make it positively charged (the + sign in the superscript) and you effecitvely end up with just a single loose proton. So the shorthand for "loose proton" is to refer to it as an H+ ion.

* pH is taught in high school science class to essentially measure the concentration of extra loose protons in, say, an aquarium. (Different fish prefer slightly different pH levels/alkilinity.) As mentioned earlier, you can interpret the term "pH" to be referring to the "p" of "H" -- the power/potency of H+ ions.

(Note that in reality, lone H+ ions do not exist in water, and instead they glom onto H2O molecules to form H3O+ and H5O2+/(H2O--H--OH2)+. If you don't know what these chemical symbols mean, don't worry about it.)

But as an H+ denier, Randall doesn't consider loose protons to be hydrogen atoms. He has a purist's view of hydrogen, that it is just "pretending" to be hydrogen as soon as it loses an electron. As a denier, he interprets the term "pH" as referring to the concentration of "pretend Hyodrgen."

==Transcript==
:[Hairbun stands behind a lectern on a podium speaking into a microphone on the lectern. A Cueball like guy stands to the left and another Cueball like guy and Megan stand to the right. There is a large sign hanging in the background along with some ornaments.]
:Sign: Grand Opening
:Hairbun: Our lab will be working on chemistry's top unsolved problems: arbitrary enzyme design, protein folding, depolymerization, and, of course, the biggest one of all:
:Hairbun: ''Figuring out what the "p" in "pH" stands for.''

{{comic discussion}}

[[Category:Comics featuring Hairbun]]
[[Category:Comics featuring Cueball]]
[[Category:Comics featuring Megan]]
[[Category:Multiple Cueballs]]
[[Category:Chemistry]]

2943: Unsolved Chemistry Problems

2024-06-09T19:16:54Z

Grandfatherclock: Correct music terminology typo.

{{comic
| number = 2943
| date = June 7, 2024
| title = Unsolved Chemistry Problems
| image = unsolved_chemistry_problems_2x.png
| imagesize = 361x386px
| noexpand = true
| titletext = I'm an H⁺ denier, in that I refuse to consider loose protons to be real hydrogen, so I personally believe it stands for 'pretend'.
}}

==Explanation==
{{incomplete|Created by a caffeinated biochemist - Please change this comment when editing this page. Do NOT delete this tag too soon.}}

There is a list of mathematical problems that are yet to be solved (such as P=NP). This comic makes a spin on it, by stating that there are (as of yet) unsolved chemistry problems. The scientist at what is apparently the "grand opening" of a new chemistry lab lists several real chemistry problems, followed by one also-unsolved-but-less-scientific problem (the p in pH)

'''Arbitrary Enzyme Design:'''

{{w|Enzymes}} are catalytic proteins. Enzyme catalysis is often unique in comparison with other catalysis methods as it is highly specific, or tailored to a specific reaction. As such, enzyme catalysis, besides being the basis of all biochemical processes, is becoming increasing relevant to industrial synthesis processes. As enzymes can be easily synthetically produced through recombinant gene technology, being able to design an arbitrary enzyme for any reaction means that effectively any reaction can be relatively easily catalyzed, revolutionizing the chemical synthesis industry.

'''Protein Folding:'''

{{w|Protein|Proteins}} are large molecules that consist of chains of amino acids. These amino acids chains become {{w|Protein Folding|folded}} in extremely complex ways into intricate 3D structures, and the way a protein is folded is of critical importance to its function. Because of the huge importance of proteins to biological life, biologists have devoted significant attention over many decades to the problem of {{w|Protein structure prediction|protein structure prediction}}. This refers to the ability to predict the 3D structure of a protein based on the amino acid sequence, and remains one of the most important problems in computational biology. The ability to predict protein structure purely from amino acid sequence, the so-called "de novo" prediction, is known in computational biology as an unusually difficult problem due to the complexity of amino acid chains. Known as "Levinthal's paradox," the number of possible conformations from the backbone conformations alone is estimated to have in the ballpark of 10^300 different conformations. Despite this, protein folding occurs extremely quickly in reality. Because of this difficulty in sampling conformations, even with optimization, such as secondary structure prediction and Monte Carlo simulation, a "true" accurate simulation is extremely computationally expensive. Because of this, the most accurate solutions, such as AlphaFold, utilize a combination of homology modeling - sampling experimentally determined proteins with similar sequences to infer structural motifs and similarities - and deep learning to accurately guess protein structure.

'''Depolymerization:'''

Polymers are very large molecules formed out of repeating subunits called monomers. Monomers are molecules, typically organic in nature, that can bond with at least 2 other molecules, making long chains or networks. That process is known as polymerization. Depolymerization is breaking down polymers into the small molecules they were originally made from. This is done through a variety of processes such as using radiation, electrolysis, adding chemicals, and other means. Plastics are the best-known polymers, but cellulose, proteins, and DNA are also technically polymers. The huge number of varieties and mixtures in plastics makes recycling them a huge challenge, and there is increasing concern about plastic waste damaging the environment.

Polymerization is usually exothermic, releasing energy as heat. To reverse this would require adding energy, in a targeted way. Simply ''destroying'' a polymer, by means of highly-reactive chemicals, heat, or radiation, doesn't generally release the monomer molecules to a significant degree; most of the reaction products are highly degraded. Most polymers are made by a process of catalysis, with the small monomer molecules interacting via a catalyst structure, often in liquid form, and the eventual product is usually solid. To reverse this would require getting the catalyst to interact in a very precise way with the solid polymer, and it's relatively difficult for the catalyst structure to get into the proper configuration with the solid tangled polymer molecules.

Another highly-desired depolymerization process would be to convert cellulose into its component glucose molecules. That glucose could then be used for a variety of different purposes, including fermentation to alcohol to use as a fuel. Currently, when plants are grown, much of the solar energy and carbon dioxide they absorb ends up in the form of cellulose rather than as starch, sugar, protein, or other substances that we find useful. Our being able to make use of the cellulose would make farming much more energy-efficient. Some organisms are able to depolymerize cellulose by means of enzymes, but our ability to use similar processes on an industrial scale is still limited. (Those organisms use a complex multi-step biochemical process which essentially "invests" energy into splitting off a glucose molecule, then recoups the investment by metabolizing the glucose.) It's also possible to depolymerize cellulose at high temperature and pressure using nothing more than water and acid, but that process is energy-intensive. It ''might'' be possible to do it with a solar-heated reactor.

'''What the “p” in pH stands for:'''

“p” shows up in pH, pKa, pKb, and other things related to the concentration of H+ ions and OH- ions. The meaning of the "p" in "pH" has been the subject of much dispute. It is sometimes referred to as "power of Hydrogen", but it's not at all clear in English what this means - are we talking about hydrogen fuel cells, or someone's superpower? The connection - which most teachers (original research) do not make - is that this "power" should be understood in the sense of "x to the third power." pH is a logarithmic scale, and the logarithm is the inverse of the exponent, and, in all three languages that pH was first published in, the word for "potency" is used for exponents. The term pH was introduced by {{w|Søren Peter Lauritz Sørensen|Søren Peter Lauritz Sørensen}}, who did not publish his results in English, and more accurately translates as "hydric exponent". The letter p could stand for,in the languages in which Sørensen published: the French 'puissance' , German Potenz, or Danish potens, all referring to the concept of the "exponent" in exponential functions.

'''ρ operator'''

2000 years ago, Romans knew nothing of zero, place-value-notation, nor real numbers. Roman scribes knew integers, integer ratios, and standard oft-used ratios. In modern times, we buy and sell by the pair (pr), dozen (dz), and score (sc). Roman shipping used ρ and ρρ to represent 4/5 and 5/8 sizes. As [https://en.wikipedia.org/wiki/Greek_numerals Ionian numerals] gave way to decimal point use, ρ use became archaic, remaining only in a few fields like music, art, and chemistry.

Over centuries, ρ gradually evolved into a real number operator as log base cube root of 2 (musical minor third), square root of golden ratio, tenth root of 10, or 10 (chemical strength, statistical power of effect). Lacking greek letter ρ printers began using latin p instead.

'''Title Text: Hydrogen Denier'''

In the title text, Randall claims to be an H+ denier by refusing to consider loose protons to be hydrogen atoms, and as such, the “p” stands for pretend. Part of the joke is Randall's implication that this is a well-known conspiracy theory that he personally buys into (it isn't). The word "denier" is often used as shorthand for other conspiracy theories, such as a "climate change denier" or a "moon landing denier."

Here's a breakdown of this joke:

* H+ is the chemical symbol for a positively-charged atom of hydrogen, the smallest atom on the Periodic Table. Since hydrogen is normally just one proton and one electron, when you take the electron away, you make it positively charged (the + sign in the superscript) and you effecitvely end up with just a single loose proton. So the shorthand for "loose proton" is to refer to it as an H+ ion.

* pH is taught in high school science class to essentially measure the concentration of extra loose protons in, say, an aquarium. (Different fish prefer slightly different pH levels/alkilinity.) As mentioned earlier, you can interpret the term "pH" to be referring to the "p" of "H" -- the power/potency of H+ ions.

(Note that in reality, lone H+ ions do not exist in water, and instead they glom onto H2O molecules to form H3O+ and H5O2+/(H2O--H--OH2)+. If you don't know what these chemical symbols mean, don't worry about it.)

But as an H+ denier, Randall doesn't consider loose protons to be hydrogen atoms. He has a purist's view of hydrogen, that it is just "pretending" to be hydrogen as soon as it loses an electron. As a denier, he interprets the term "pH" as referring to the concentration of "pretend Hyodrgen."

==Transcript==
:[Hairbun stands behind a lectern on a podium speaking into a microphone on the lectern. A Cueball like guy stands to the left and another Cueball like guy and Megan stand to the right. There is a large sign hanging in the background along with some ornaments.]
:Sign: Grand Opening
:Hairbun: Our lab will be working on chemistry's top unsolved problems: arbitrary enzyme design, protein folding, depolymerization, and, of course, the biggest one of all:
:Hairbun: ''Figuring out what the "p" in "pH" stands for.''

{{comic discussion}}

[[Category:Comics featuring Hairbun]]
[[Category:Comics featuring Cueball]]
[[Category:Comics featuring Megan]]
[[Category:Multiple Cueballs]]
[[Category:Chemistry]]

2943: Unsolved Chemistry Problems

2024-06-09T19:08:16Z

Grandfatherclock: Corrected subject predicate plurality agreement.

{{comic
| number = 2943
| date = June 7, 2024
| title = Unsolved Chemistry Problems
| image = unsolved_chemistry_problems_2x.png
| imagesize = 361x386px
| noexpand = true
| titletext = I'm an H⁺ denier, in that I refuse to consider loose protons to be real hydrogen, so I personally believe it stands for 'pretend'.
}}

==Explanation==
{{incomplete|Created by a caffeinated biochemist - Please change this comment when editing this page. Do NOT delete this tag too soon.}}

There is a list of mathematical problems that are yet to be solved (such as P=NP). This comic makes a spin on it, by stating that there are (as of yet) unsolved chemistry problems. The scientist at what is apparently the "grand opening" of a new chemistry lab lists several real chemistry problems, followed by one also-unsolved-but-less-scientific problem (the p in pH)

'''Arbitrary Enzyme Design:'''

{{w|Enzymes}} are catalytic proteins. Enzyme catalysis is often unique in comparison with other catalysis methods as it is highly specific, or tailored to a specific reaction. As such, enzyme catalysis, besides being the basis of all biochemical processes, is becoming increasing relevant to industrial synthesis processes. As enzymes can be easily synthetically produced through recombinant gene technology, being able to design an arbitrary enzyme for any reaction means that effectively any reaction can be relatively easily catalyzed, revolutionizing the chemical synthesis industry.

'''Protein Folding:'''

{{w|Protein|Proteins}} are large molecules that consist of chains of amino acids. These amino acids chains become {{w|Protein Folding|folded}} in extremely complex ways into intricate 3D structures, and the way a protein is folded is of critical importance to its function. Because of the huge importance of proteins to biological life, biologists have devoted significant attention over many decades to the problem of {{w|Protein structure prediction|protein structure prediction}}. This refers to the ability to predict the 3D structure of a protein based on the amino acid sequence, and remains one of the most important problems in computational biology. The ability to predict protein structure purely from amino acid sequence, the so-called "de novo" prediction, is known in computational biology as an unusually difficult problem due to the complexity of amino acid chains. Known as "Levinthal's paradox," the number of possible conformations from the backbone conformations alone is estimated to have in the ballpark of 10^300 different conformations. Despite this, protein folding occurs extremely quickly in reality. Because of this difficulty in sampling conformations, even with optimization, such as secondary structure prediction and Monte Carlo simulation, a "true" accurate simulation is extremely computationally expensive. Because of this, the most accurate solutions, such as AlphaFold, utilize a combination of homology modeling - sampling experimentally determined proteins with similar sequences to infer structural motifs and similarities - and deep learning to accurately guess protein structure.

'''Depolymerization:'''

Polymers are very large molecules formed out of repeating subunits called monomers. Monomers are molecules, typically organic in nature, that can bond with at least 2 other molecules, making long chains or networks. That process is known as polymerization. Depolymerization is breaking down polymers into the small molecules they were originally made from. This is done through a variety of processes such as using radiation, electrolysis, adding chemicals, and other means. Plastics are the best-known polymers, but cellulose, proteins, and DNA are also technically polymers. The huge number of varieties and mixtures in plastics makes recycling them a huge challenge, and there is increasing concern about plastic waste damaging the environment.

Polymerization is usually exothermic, releasing energy as heat. To reverse this would require adding energy, in a targeted way. Simply ''destroying'' a polymer, by means of highly-reactive chemicals, heat, or radiation, doesn't generally release the monomer molecules to a significant degree; most of the reaction products are highly degraded. Most polymers are made by a process of catalysis, with the small monomer molecules interacting via a catalyst structure, often in liquid form, and the eventual product is usually solid. To reverse this would require getting the catalyst to interact in a very precise way with the solid polymer, and it's relatively difficult for the catalyst structure to get into the proper configuration with the solid tangled polymer molecules.

Another highly-desired depolymerization process would be to convert cellulose into its component glucose molecules. That glucose could then be used for a variety of different purposes, including fermentation to alcohol to use as a fuel. Currently, when plants are grown, much of the solar energy and carbon dioxide they absorb ends up in the form of cellulose rather than as starch, sugar, protein, or other substances that we find useful. Our being able to make use of the cellulose would make farming much more energy-efficient. Some organisms are able to depolymerize cellulose by means of enzymes, but our ability to use similar processes on an industrial scale is still limited. (Those organisms use a complex multi-step biochemical process which essentially "invests" energy into splitting off a glucose molecule, then recoups the investment by metabolizing the glucose.) It's also possible to depolymerize cellulose at high temperature and pressure using nothing more than water and acid, but that process is energy-intensive. It ''might'' be possible to do it with a solar-heated reactor.

'''What the “p” in pH stands for:'''

“p” shows up in pH, pKa, pKb, and other things related to the concentration of H+ ions and OH- ions. The meaning of the "p" in "pH" has been the subject of much dispute. It is sometimes referred to as "power of Hydrogen", but it's not at all clear in English what this means - are we talking about hydrogen fuel cells, or someone's superpower? The connection - which most teachers (original research) do not make - is that this "power" should be understood in the sense of "x to the third power." pH is a logarithmic scale, and the logarithm is the inverse of the exponent, and, in all three languages that pH was first published in, the word for "potency" is used for exponents. The term pH was introduced by {{w|Søren Peter Lauritz Sørensen|Søren Peter Lauritz Sørensen}}, who did not publish his results in English, and more accurately translates as "hydric exponent". The letter p could stand for,in the languages in which Sørensen published: the French 'puissance' , German Potenz, or Danish potens, all referring to the concept of the "exponent" in exponential functions.

'''ρ operator'''

2000 years ago, Romans knew nothing of zero, place-value-notation, nor real numbers. Roman scribes knew integers, integer ratios, and standard oft-used ratios. In modern times, we buy and sell by the pair (pr), dozen (dz), and score (sc). Roman shipping used ρ and ρρ to represent 4/5 and 5/8 sizes. As [https://en.wikipedia.org/wiki/Greek_numerals Ionian numerals] gave way to decimal point use, ρ use became archaic, remaining only in a few fields like music, art, and chemistry.

Over centuries, ρ gradually evolved into a real number operator as log base cube root of 2 (musical major third), square root of golden ratio, tenth root of 10, or 10 (chemical strength, statistical power of effect). Lacking greek letter ρ printers began using latin p instead.

'''Title Text: Hydrogen Denier'''

In the title text, Randall claims to be an H+ denier by refusing to consider loose protons to be hydrogen atoms, and as such, the “p” stands for pretend. Part of the joke is Randall's implication that this is a well-known conspiracy theory that he personally buys into (it isn't). The word "denier" is often used as shorthand for other conspiracy theories, such as a "climate change denier" or a "moon landing denier."

Here's a breakdown of this joke:

* H+ is the chemical symbol for a positively-charged atom of hydrogen, the smallest atom on the Periodic Table. Since hydrogen is normally just one proton and one electron, when you take the electron away, you make it positively charged (the + sign in the superscript) and you effecitvely end up with just a single loose proton. So the shorthand for "loose proton" is to refer to it as an H+ ion.

* pH is taught in high school science class to essentially measure the concentration of extra loose protons in, say, an aquarium. (Different fish prefer slightly different pH levels/alkilinity.) As mentioned earlier, you can interpret the term "pH" to be referring to the "p" of "H" -- the power/potency of H+ ions.

(Note that in reality, lone H+ ions do not exist in water, and instead they glom onto H2O molecules to form H3O+ and H5O2+/(H2O--H--OH2)+. If you don't know what these chemical symbols mean, don't worry about it.)

But as an H+ denier, Randall doesn't consider loose protons to be hydrogen atoms. He has a purist's view of hydrogen, that it is just "pretending" to be hydrogen as soon as it loses an electron. As a denier, he interprets the term "pH" as referring to the concentration of "pretend Hyodrgen."

==Transcript==
:[Hairbun stands behind a lectern on a podium speaking into a microphone on the lectern. A Cueball like guy stands to the left and another Cueball like guy and Megan stand to the right. There is a large sign hanging in the background along with some ornaments.]
:Sign: Grand Opening
:Hairbun: Our lab will be working on chemistry's top unsolved problems: arbitrary enzyme design, protein folding, depolymerization, and, of course, the biggest one of all:
:Hairbun: ''Figuring out what the "p" in "pH" stands for.''

{{comic discussion}}

[[Category:Comics featuring Hairbun]]
[[Category:Comics featuring Cueball]]
[[Category:Comics featuring Megan]]
[[Category:Multiple Cueballs]]
[[Category:Chemistry]]

2943: Unsolved Chemistry Problems

2024-06-09T18:30:12Z

Grandfatherclock: Slight historical connection.

{{comic
| number = 2943
| date = June 7, 2024
| title = Unsolved Chemistry Problems
| image = unsolved_chemistry_problems_2x.png
| imagesize = 361x386px
| noexpand = true
| titletext = I'm an H⁺ denier, in that I refuse to consider loose protons to be real hydrogen, so I personally believe it stands for 'pretend'.
}}

==Explanation==
{{incomplete|Created by a caffeinated biochemist - Please change this comment when editing this page. Do NOT delete this tag too soon.}}

There is a list of mathematical problems that are yet to be solved (such as P=NP). This comic makes a spin on it, by stating that there are (as of yet) unsolved chemistry problems. The scientist at what is apparently the "grand opening" of a new chemistry lab lists several real chemistry problems, followed by one also-unsolved-but-less-scientific problem (the p in pH)

'''Arbitrary Enzyme Design:'''

{{w|Enzymes}} are catalytic proteins. Enzyme catalysis is often unique in comparison with other catalysis methods as it is highly specific, or tailored to a specific reaction. As such, enzyme catalysis, besides being the basis of all biochemical processes, is becoming increasing relevant to industrial synthesis processes. As enzymes can be easily synthetically produced through recombinant gene technology, being able to design an arbitrary enzyme for any reaction means that effectively any reaction can be relatively easily catalyzed, revolutionizing the chemical synthesis industry.

'''Protein Folding:'''

{{w|Protein|Proteins}} are large molecules that consist of chains of amino acids. These amino acids chains become {{w|Protein Folding|folded}} in extremely complex ways into intricate 3D structures, and the way a protein is folded is of critical importance to its function. Because of the huge importance of proteins to biological life, biologists have devoted significant attention over many decades to the problem of {{w|Protein structure prediction|protein structure prediction}}. This refers to the ability to predict the 3D structure of a protein based on the amino acid sequence, and remains one of the most important problems in computational biology. The ability to predict protein structure purely from amino acid sequence, the so-called "de novo" prediction, is known in computational biology as an unusually difficult problem due to the complexity of amino acid chains. Known as "Levinthal's paradox," the number of possible conformations from the backbone conformations alone is estimated to have in the ballpark of 10^300 different conformations. Despite this, protein folding occurs extremely quickly in reality. Because of this difficulty in sampling conformations, even with optimization, such as secondary structure prediction and Monte Carlo simulation, a "true" accurate simulation is extremely computationally expensive. Because of this, the most accurate solutions, such as AlphaFold, utilize a combination of homology modeling - sampling experimentally determined proteins with similar sequences to infer structural motifs and similarities - and deep learning to accurately guess protein structure.

'''Depolymerization:'''

Polymers are very large molecules formed out of repeating subunits called monomers. Monomers are molecules, typically organic in nature, that can bond with at least 2 other molecules, making long chains or networks. That process is known as polymerization. Depolymerization is breaking down polymers into the small molecules they were originally made from. This is done through a variety of processes such as using radiation, electrolysis, adding chemicals, and other means. Plastics are the best-known polymers, but cellulose, proteins, and DNA are also technically polymers. The huge number of varieties and mixtures in plastics makes recycling them a huge challenge, and there is increasing concern about plastic waste damaging the environment.

Polymerization is usually exothermic, releasing energy as heat. To reverse this would require adding energy, in a targeted way. Simply ''destroying'' a polymer, by means of highly-reactive chemicals, heat, or radiation, doesn't generally release the monomer molecules to a significant degree; most of the reaction products are highly degraded. Most polymers are made by a process of catalysis, with the small monomer molecules interacting via a catalyst structure, often in liquid form, and the eventual product is usually solid. To reverse this would require getting the catalyst to interact in a very precise way with the solid polymer, and it's relatively difficult for the catalyst structure to get into the proper configuration with the solid tangled polymer molecules.

Another highly-desired depolymerization process would be to convert cellulose into its component glucose molecules. That glucose could then be used for a variety of different purposes, including fermentation to alcohol to use as a fuel. Currently, when plants are grown, much of the solar energy and carbon dioxide they absorb ends up in the form of cellulose rather than as starch, sugar, protein, or other substances that we find useful. Our being able to make use of the cellulose would make farming much more energy-efficient. Some organisms are able to depolymerize cellulose by means of enzymes, but our ability to use similar processes on an industrial scale is still limited. (Those organisms use a complex multi-step biochemical process which essentially "invests" energy into splitting off a glucose molecule, then recoups the investment by metabolizing the glucose.) It's also possible to depolymerize cellulose at high temperature and pressure using nothing more than water and acid, but that process is energy-intensive. It ''might'' be possible to do it with a solar-heated reactor.

'''What the “p” in pH stands for:'''

“p” shows up in pH, pKa, pKb, and other things related to the concentration of H+ ions and OH- ions. The meaning of the "p" in "pH" has been the subject of much dispute. It is sometimes referred to as "power of Hydrogen", but it's not at all clear in English what this means - are we talking about hydrogen fuel cells, or someone's superpower? The connection - which most teachers (original research) do not make - is that this "power" should be understood in the sense of "x to the third power." pH is a logarithmic scale, and the logarithm is the inverse of the exponent, and, in all three languages that pH was first published in, the word for "potency" is used for exponents. The term pH was introduced by {{w|Søren Peter Lauritz Sørensen|Søren Peter Lauritz Sørensen}}, who did not publish his results in English, and more accurately translates as "hydric exponent". The letter p could stand for,in the languages in which Sørensen published: the French 'puissance' , German Potenz, or Danish potens, all referring to the concept of the "exponent" in exponential functions.

'''ρ operator'''

2000 years ago, Roman knew nothing of zero, place-value-notation, nor real numbers. Roman scribes knew integers, integer ratios, and standard oft-used ratios. In modern times, we buy and sell by the pair (pr), dozen (dz), and score (sc). Roman shipping used ρ and ρρ to represent 4/5 and 5/8 sizes. As [https://en.wikipedia.org/wiki/Greek_numerals Ionian numerals] gave way to decimal point use, ρ use became archaic, remaining only in a few fields like music, art, and chemistry.
ρ gradually evolved into a real number operator as log base cube root of 2 (musical major third), square root of golden ratio, tenth root of 10, or 10 (chemical strength, statistical power of effect). Lacking greek letter ρ printers began using latin p instead.

'''Title Text: Hydrogen Denier'''

In the title text, Randall claims to be an H+ denier by refusing to consider loose protons to be hydrogen atoms, and as such, the “p” stands for pretend. Part of the joke is Randall's implication that this is a well-known conspiracy theory that he personally buys into (it isn't). The word "denier" is often used as shorthand for other conspiracy theories, such as a "climate change denier" or a "moon landing denier."

Here's a breakdown of this joke:

* H+ is the chemical symbol for a positively-charged atom of hydrogen, the smallest atom on the Periodic Table. Since hydrogen is normally just one proton and one electron, when you take the electron away, you make it positively charged (the + sign in the superscript) and you effecitvely end up with just a single loose proton. So the shorthand for "loose proton" is to refer to it as an H+ ion.

* pH is taught in high school science class to essentially measure the concentration of extra loose protons in, say, an aquarium. (Different fish prefer slightly different pH levels/alkilinity.) As mentioned earlier, you can interpret the term "pH" to be referring to the "p" of "H" -- the power/potency of H+ ions.

(Note that in reality, lone H+ ions do not exist in water, and instead they glom onto H2O molecules to form H3O+ and H5O2+/(H2O--H--OH2)+. If you don't know what these chemical symbols mean, don't worry about it.)

But as an H+ denier, Randall doesn't consider loose protons to be hydrogen atoms. He has a purist's view of hydrogen, that it is just "pretending" to be hydrogen as soon as it loses an electron. As a denier, he interprets the term "pH" as referring to the concentration of "pretend Hyodrgen."

==Transcript==
:[Hairbun stands behind a lectern on a podium speaking into a microphone on the lectern. A Cueball like guy stands to the left and another Cueball like guy and Megan stand to the right. There is a large sign hanging in the background along with some ornaments.]
:Sign: Grand Opening
:Hairbun: Our lab will be working on chemistry's top unsolved problems: arbitrary enzyme design, protein folding, depolymerization, and, of course, the biggest one of all:
:Hairbun: ''Figuring out what the "p" in "pH" stands for.''

{{comic discussion}}

[[Category:Comics featuring Hairbun]]
[[Category:Comics featuring Cueball]]
[[Category:Comics featuring Megan]]
[[Category:Multiple Cueballs]]
[[Category:Chemistry]]

2943: Unsolved Chemistry Problems

2024-06-09T18:19:55Z

Grandfatherclock: Add description of rho mathematical statistics operator.

{{comic
| number = 2943
| date = June 7, 2024
| title = Unsolved Chemistry Problems
| image = unsolved_chemistry_problems_2x.png
| imagesize = 361x386px
| noexpand = true
| titletext = I'm an H⁺ denier, in that I refuse to consider loose protons to be real hydrogen, so I personally believe it stands for 'pretend'.
}}

==Explanation==
{{incomplete|Created by a caffeinated biochemist - Please change this comment when editing this page. Do NOT delete this tag too soon.}}

There is a list of mathematical problems that are yet to be solved (such as P=NP). This comic makes a spin on it, by stating that there are (as of yet) unsolved chemistry problems. The scientist at what is apparently the "grand opening" of a new chemistry lab lists several real chemistry problems, followed by one also-unsolved-but-less-scientific problem (the p in pH)

'''Arbitrary Enzyme Design:'''

{{w|Enzymes}} are catalytic proteins. Enzyme catalysis is often unique in comparison with other catalysis methods as it is highly specific, or tailored to a specific reaction. As such, enzyme catalysis, besides being the basis of all biochemical processes, is becoming increasing relevant to industrial synthesis processes. As enzymes can be easily synthetically produced through recombinant gene technology, being able to design an arbitrary enzyme for any reaction means that effectively any reaction can be relatively easily catalyzed, revolutionizing the chemical synthesis industry.

'''Protein Folding:'''

{{w|Protein|Proteins}} are large molecules that consist of chains of amino acids. These amino acids chains become {{w|Protein Folding|folded}} in extremely complex ways into intricate 3D structures, and the way a protein is folded is of critical importance to its function. Because of the huge importance of proteins to biological life, biologists have devoted significant attention over many decades to the problem of {{w|Protein structure prediction|protein structure prediction}}. This refers to the ability to predict the 3D structure of a protein based on the amino acid sequence, and remains one of the most important problems in computational biology. The ability to predict protein structure purely from amino acid sequence, the so-called "de novo" prediction, is known in computational biology as an unusually difficult problem due to the complexity of amino acid chains. Known as "Levinthal's paradox," the number of possible conformations from the backbone conformations alone is estimated to have in the ballpark of 10^300 different conformations. Despite this, protein folding occurs extremely quickly in reality. Because of this difficulty in sampling conformations, even with optimization, such as secondary structure prediction and Monte Carlo simulation, a "true" accurate simulation is extremely computationally expensive. Because of this, the most accurate solutions, such as AlphaFold, utilize a combination of homology modeling - sampling experimentally determined proteins with similar sequences to infer structural motifs and similarities - and deep learning to accurately guess protein structure.

'''Depolymerization:'''

Polymers are very large molecules formed out of repeating subunits called monomers. Monomers are molecules, typically organic in nature, that can bond with at least 2 other molecules, making long chains or networks. That process is known as polymerization. Depolymerization is breaking down polymers into the small molecules they were originally made from. This is done through a variety of processes such as using radiation, electrolysis, adding chemicals, and other means. Plastics are the best-known polymers, but cellulose, proteins, and DNA are also technically polymers. The huge number of varieties and mixtures in plastics makes recycling them a huge challenge, and there is increasing concern about plastic waste damaging the environment.

Polymerization is usually exothermic, releasing energy as heat. To reverse this would require adding energy, in a targeted way. Simply ''destroying'' a polymer, by means of highly-reactive chemicals, heat, or radiation, doesn't generally release the monomer molecules to a significant degree; most of the reaction products are highly degraded. Most polymers are made by a process of catalysis, with the small monomer molecules interacting via a catalyst structure, often in liquid form, and the eventual product is usually solid. To reverse this would require getting the catalyst to interact in a very precise way with the solid polymer, and it's relatively difficult for the catalyst structure to get into the proper configuration with the solid tangled polymer molecules.

Another highly-desired depolymerization process would be to convert cellulose into its component glucose molecules. That glucose could then be used for a variety of different purposes, including fermentation to alcohol to use as a fuel. Currently, when plants are grown, much of the solar energy and carbon dioxide they absorb ends up in the form of cellulose rather than as starch, sugar, protein, or other substances that we find useful. Our being able to make use of the cellulose would make farming much more energy-efficient. Some organisms are able to depolymerize cellulose by means of enzymes, but our ability to use similar processes on an industrial scale is still limited. (Those organisms use a complex multi-step biochemical process which essentially "invests" energy into splitting off a glucose molecule, then recoups the investment by metabolizing the glucose.) It's also possible to depolymerize cellulose at high temperature and pressure using nothing more than water and acid, but that process is energy-intensive. It ''might'' be possible to do it with a solar-heated reactor.

'''What the “p” in pH stands for:'''

“p” shows up in pH, pKa, pKb, and other things related to the concentration of H+ ions and OH- ions. The meaning of the "p" in "pH" has been the subject of much dispute. It is sometimes referred to as "power of Hydrogen", but it's not at all clear in English what this means - are we talking about hydrogen fuel cells, or someone's superpower? The connection - which most teachers (original research) do not make - is that this "power" should be understood in the sense of "x to the third power." pH is a logarithmic scale, and the logarithm is the inverse of the exponent, and, in all three languages that pH was first published in, the word for "potency" is used for exponents. The term pH was introduced by {{w|Søren Peter Lauritz Sørensen|Søren Peter Lauritz Sørensen}}, who did not publish his results in English, and more accurately translates as "hydric exponent". The letter p could stand for,in the languages in which Sørensen published: the French 'puissance' , German Potenz, or Danish potens, all referring to the concept of the "exponent" in exponential functions.

'''ρ operator'''

2000 years ago, Roman knew nothing of zero, place-value-notation, nor real numbers. Roman scribes knew integers, integer ratios, and standard oft-used ratios. In modern times, we buy and sell by the pair (pr), dozen (dz), and score (sc). Roman shipping used ρ and ρρ to represent 4/5 and 5/8 sizes. As [https://en.wikipedia.org/wiki/Greek_numerals Ionian numerals] gave way to decimal point use, ρ use became archaic, remaining only in a few fields like music, art, and chemistry.
ρ gradually evolved into a real number operator as log base cube root of 2 (musical major third), square root of golden ratio, or tenth root of 10 (chemical strength, statistical power of effect). Lacking greek letter ρ printers began using latin p instead.

'''Title Text: Hydrogen Denier'''

In the title text, Randall claims to be an H+ denier by refusing to consider loose protons to be hydrogen atoms, and as such, the “p” stands for pretend. Part of the joke is Randall's implication that this is a well-known conspiracy theory that he personally buys into (it isn't). The word "denier" is often used as shorthand for other conspiracy theories, such as a "climate change denier" or a "moon landing denier."

Here's a breakdown of this joke:

* H+ is the chemical symbol for a positively-charged atom of hydrogen, the smallest atom on the Periodic Table. Since hydrogen is normally just one proton and one electron, when you take the electron away, you make it positively charged (the + sign in the superscript) and you effecitvely end up with just a single loose proton. So the shorthand for "loose proton" is to refer to it as an H+ ion.

* pH is taught in high school science class to essentially measure the concentration of extra loose protons in, say, an aquarium. (Different fish prefer slightly different pH levels/alkilinity.) As mentioned earlier, you can interpret the term "pH" to be referring to the "p" of "H" -- the power/potency of H+ ions.

(Note that in reality, lone H+ ions do not exist in water, and instead they glom onto H2O molecules to form H3O+ and H5O2+/(H2O--H--OH2)+. If you don't know what these chemical symbols mean, don't worry about it.)

But as an H+ denier, Randall doesn't consider loose protons to be hydrogen atoms. He has a purist's view of hydrogen, that it is just "pretending" to be hydrogen as soon as it loses an electron. As a denier, he interprets the term "pH" as referring to the concentration of "pretend Hyodrgen."

==Transcript==
:[Hairbun stands behind a lectern on a podium speaking into a microphone on the lectern. A Cueball like guy stands to the left and another Cueball like guy and Megan stand to the right. There is a large sign hanging in the background along with some ornaments.]
:Sign: Grand Opening
:Hairbun: Our lab will be working on chemistry's top unsolved problems: arbitrary enzyme design, protein folding, depolymerization, and, of course, the biggest one of all:
:Hairbun: ''Figuring out what the "p" in "pH" stands for.''

{{comic discussion}}

[[Category:Comics featuring Hairbun]]
[[Category:Comics featuring Cueball]]
[[Category:Comics featuring Megan]]
[[Category:Multiple Cueballs]]
[[Category:Chemistry]]