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		<updated>2026-04-29T19:28:44Z</updated>
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	<entry>
		<id>https://www.explainxkcd.com/wiki/index.php?title=2943:_Unsolved_Chemistry_Problems&amp;diff=344007</id>
		<title>2943: Unsolved Chemistry Problems</title>
		<link rel="alternate" type="text/html" href="https://www.explainxkcd.com/wiki/index.php?title=2943:_Unsolved_Chemistry_Problems&amp;diff=344007"/>
				<updated>2024-06-07T20:09:08Z</updated>
		
		<summary type="html">&lt;p&gt;ReadEuler: More detail about protein folding&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{comic&lt;br /&gt;
| number    = 2943&lt;br /&gt;
| date      = June 7, 2024&lt;br /&gt;
| title     = Unsolved Chemistry Problems&lt;br /&gt;
| image     = unsolved_chemistry_problems_2x.png&lt;br /&gt;
| imagesize = 361x386px&lt;br /&gt;
| noexpand  = true&lt;br /&gt;
| titletext = I'm an H⁺ denier, in that I refuse to consider loose protons to be real hydrogen, so I personally believe it stands for 'pretend'.&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
==Explanation==&lt;br /&gt;
{{incomplete|Created by a Loose Proton Called H+ - Please change this comment when editing this page. Do NOT delete this tag too soon.}}&lt;br /&gt;
&lt;br /&gt;
There is a list of mathematical problems that are yet to be solved (such as P=NP). This comic makes a spin on it, by stating that there are (as of yet) unsolved chemistry problems. &lt;br /&gt;
&lt;br /&gt;
'''Arbitrary Enzyme Design:'''&lt;br /&gt;
&lt;br /&gt;
'''Protein Folding:'''  &lt;br /&gt;
&lt;br /&gt;
{{w|Protein|Proteins}} are large molecules that consist of chains of amino acids.  These amino acids chains become folded {{w|Protein Folding|folded}} in extremely complex ways into intricate 3D structures, and the way a protein is folded is of critical importance to its function.  &amp;quot;Misfolded&amp;quot; proteins like {{w|Prion|prions}} can be inactive or cause other proteins to become misfolded, which can lead to fatal illnesses. Because of the huge importance of proteins to biological life, biologists have devoted significant attention over many decades to the problem of {{w|Protein structure prediction|protein structure prediction}}.  This refers to the ability to predict the 3D structure of a protein based on the amino acid sequence, and remains one of the most important problems in computational biology.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Depolymerization:'''&lt;br /&gt;
&lt;br /&gt;
'''What the “p” in pH stands for:'''&lt;br /&gt;
&lt;br /&gt;
“p” shows up in pH, pKa, pKb, and other things related to the concentration of H+ ions and OH- ions.  The meaning of the &amp;quot;p&amp;quot; in &amp;quot;pH&amp;quot; has been the subject of much dispute.  It is sometimes referred to as &amp;quot;power of Hydrogen&amp;quot;, but the term was introduced by {{w|Søren Peter Lauritz Sørensen|Søren Peter Lauritz Sørensen}}, who did not publish his results in English. The letter p could stand for the French puissance, German Potenz, or Danish potens, all meaning &amp;quot;power&amp;quot;, or it could mean &amp;quot;potential&amp;quot;. All of these words start with the letter p in French, German, and Danish, which were the languages in which Sørensen published.&lt;br /&gt;
&lt;br /&gt;
Someone, presumably Randall Monroe, claims that they refuse to believe that loose protons are hydrogen atoms, and as such, the “p” stands for pretend. This could work, by saying that it is the pretend Ka and the Pretend Kb. However, Hydrogen atoms and loose protons both have a single proton. An Ion is any atom with a number of electrons not equal to the amount of protons in an atom. This counts for both more electrons (Anions), and less electrons (Cations). &lt;br /&gt;
&lt;br /&gt;
==Transcript==&lt;br /&gt;
{{incomplete transcript|Do NOT delete this tag too soon.}}&lt;br /&gt;
&lt;br /&gt;
:[Hairbun stands behind a lectern on a podium with two Cueballs and Megan standing behind her. There is a &amp;quot;Grand Opening&amp;quot; sign hanging in the background along with some ornaments.]&lt;br /&gt;
:Hairbun: Our lab will be working on chemistry's top unsolved problems: arbitrary enzyme design, protein folding, depolymerization, and, of course, the biggest one of all:&lt;br /&gt;
:Hairbun: ''Figuring out what the &amp;quot;p&amp;quot; in &amp;quot;pH&amp;quot; stands for.''&lt;br /&gt;
&lt;br /&gt;
{{comic discussion}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Comics featuring Hairbun]]&lt;br /&gt;
[[Category:Comics featuring Cueball]]&lt;br /&gt;
[[Category:Comics featuring Megan]]&lt;br /&gt;
[[Category:Multiple Cueballs]]&lt;br /&gt;
[[Category:Chemistry]]&lt;/div&gt;</summary>
		<author><name>ReadEuler</name></author>	</entry>

	<entry>
		<id>https://www.explainxkcd.com/wiki/index.php?title=2943:_Unsolved_Chemistry_Problems&amp;diff=344006</id>
		<title>2943: Unsolved Chemistry Problems</title>
		<link rel="alternate" type="text/html" href="https://www.explainxkcd.com/wiki/index.php?title=2943:_Unsolved_Chemistry_Problems&amp;diff=344006"/>
				<updated>2024-06-07T19:57:55Z</updated>
		
		<summary type="html">&lt;p&gt;ReadEuler: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{comic&lt;br /&gt;
| number    = 2943&lt;br /&gt;
| date      = June 7, 2024&lt;br /&gt;
| title     = Unsolved Chemistry Problems&lt;br /&gt;
| image     = unsolved_chemistry_problems_2x.png&lt;br /&gt;
| imagesize = 361x386px&lt;br /&gt;
| noexpand  = true&lt;br /&gt;
| titletext = I'm an H⁺ denier, in that I refuse to consider loose protons to be real hydrogen, so I personally believe it stands for 'pretend'.&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
==Explanation==&lt;br /&gt;
{{incomplete|Created by a Loose Proton Called H+ - Please change this comment when editing this page. Do NOT delete this tag too soon.}}&lt;br /&gt;
&lt;br /&gt;
There is a list of mathematical problems that are yet to be solved (such as P=NP). This comic makes a spin on it, by stating that there are (as of yet) unsolved chemistry problems. &lt;br /&gt;
&lt;br /&gt;
'''Arbitrary Enzyme Design:'''&lt;br /&gt;
&lt;br /&gt;
'''Protein Folding:''' &lt;br /&gt;
{{w|Protein|Proteins}} are large molecules that consist of chains of amino acids.  These amino acids chains can be {{w|Protein Folding|folded}} in extremely complex ways, and the way a protein is folded is of critical importance to its function.  &amp;quot;Misfolded&amp;quot; proteins like {{w|Prion|prions}} can be inactive or cause other proteins to become misfolded, which can lead to fatal illnesses. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
'''Depolymerization:'''&lt;br /&gt;
&lt;br /&gt;
'''What the “p” in pH stands for:'''&lt;br /&gt;
&lt;br /&gt;
“p” shows up in pH, pKa, pKb, and other things related to the concentration of H+ ions and OH- ions.  The meaning of the &amp;quot;p&amp;quot; in &amp;quot;pH&amp;quot; has been the subject of much dispute.  It is sometimes referred to as &amp;quot;power of Hydrogen&amp;quot;, but the term was introduced by {{w|Søren Peter Lauritz Sørensen|Søren Peter Lauritz Sørensen}}, who did not publish his results in English. The letter p could stand for the French puissance, German Potenz, or Danish potens, all meaning &amp;quot;power&amp;quot;, or it could mean &amp;quot;potential&amp;quot;. All of these words start with the letter p in French, German, and Danish, which were the languages in which Sørensen published.&lt;br /&gt;
&lt;br /&gt;
Someone, presumably Randall Monroe, claims that they refuse to believe that loose protons are hydrogen atoms, and as such, the “p” stands for pretend. This could work, by saying that it is the pretend Ka and the Pretend Kb. However, Hydrogen atoms and loose protons both have a single proton. An Ion is any atom with a number of electrons not equal to the amount of protons in an atom. This counts for both more electrons (Anions), and less electrons (Cations). &lt;br /&gt;
&lt;br /&gt;
==Transcript==&lt;br /&gt;
{{incomplete transcript|Do NOT delete this tag too soon.}}&lt;br /&gt;
&lt;br /&gt;
:[Hairbun stands behind a lectern on a podium with two Cueballs and Megan standing behind her. There is a &amp;quot;Grand Opening&amp;quot; sign hanging in the background along with some ornaments.]&lt;br /&gt;
:Hairbun: Our lab will be working on chemistry's top unsolved problems: arbitrary enzyme design, protein folding, depolymerization, and, of course, the biggest one of all:&lt;br /&gt;
:Hairbun: ''Figuring out what the &amp;quot;p&amp;quot; in &amp;quot;pH&amp;quot; stands for.''&lt;br /&gt;
&lt;br /&gt;
{{comic discussion}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Comics featuring Hairbun]]&lt;br /&gt;
[[Category:Comics featuring Cueball]]&lt;br /&gt;
[[Category:Comics featuring Megan]]&lt;br /&gt;
[[Category:Multiple Cueballs]]&lt;br /&gt;
[[Category:Chemistry]]&lt;/div&gt;</summary>
		<author><name>ReadEuler</name></author>	</entry>

	<entry>
		<id>https://www.explainxkcd.com/wiki/index.php?title=2943:_Unsolved_Chemistry_Problems&amp;diff=344003</id>
		<title>2943: Unsolved Chemistry Problems</title>
		<link rel="alternate" type="text/html" href="https://www.explainxkcd.com/wiki/index.php?title=2943:_Unsolved_Chemistry_Problems&amp;diff=344003"/>
				<updated>2024-06-07T19:50:20Z</updated>
		
		<summary type="html">&lt;p&gt;ReadEuler: fix link&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{comic&lt;br /&gt;
| number    = 2943&lt;br /&gt;
| date      = June 7, 2024&lt;br /&gt;
| title     = Unsolved Chemistry Problems&lt;br /&gt;
| image     = unsolved_chemistry_problems_2x.png&lt;br /&gt;
| imagesize = 361x386px&lt;br /&gt;
| noexpand  = true&lt;br /&gt;
| titletext = I'm an H⁺ denier, in that I refuse to consider loose protons to be real hydrogen, so I personally believe it stands for 'pretend'.&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
==Explanation==&lt;br /&gt;
{{incomplete|Created by a Loose Proton Called H+ - Please change this comment when editing this page. Do NOT delete this tag too soon.}}&lt;br /&gt;
&lt;br /&gt;
There is a list of mathematical problems that are yet to be solved (such as P=NP). This comic makes a spin on it, by stating that there are (as of yet) unsolved chemistry problems. &lt;br /&gt;
&lt;br /&gt;
Arbitrary Enzyme Design:&lt;br /&gt;
&lt;br /&gt;
Protein Folding: &lt;br /&gt;
&lt;br /&gt;
Depolymerization:&lt;br /&gt;
&lt;br /&gt;
What the “p” in pH stands for:&lt;br /&gt;
&lt;br /&gt;
“p” shows up in pH, pKa, pKb, and other things related to the concentration of H+ ions and OH- ions.  The meaning of the &amp;quot;p&amp;quot; in &amp;quot;pH&amp;quot; has been the subject of much dispute.  It is sometimes referred to as &amp;quot;power of Hydrogen&amp;quot;, but the term was introduced by {{w|Søren Peter Lauritz Sørensen|Søren Peter Lauritz Sørensen}}, who did not publish his results in English. The letter p could stand for the French puissance, German Potenz, or Danish potens, all meaning &amp;quot;power&amp;quot;, or it could mean &amp;quot;potential&amp;quot;. All of these words start with the letter p in French, German, and Danish, which were the languages in which Sørensen published.&lt;br /&gt;
&lt;br /&gt;
Someone, presumably Randall Monroe, claims that they refuse to believe that loose protons are hydrogen atoms, and as such, the “p” stands for pretend. This could work, by saying that it is the pretend Ka and the Pretend Kb. However, Hydrogen atoms and loose protons both have a single proton. An Ion is any atom with a number of electrons not equal to the amount of protons in an atom. This counts for both more electrons (Anions), and less electrons (Cations). &lt;br /&gt;
&lt;br /&gt;
==Transcript==&lt;br /&gt;
{{incomplete transcript|Do NOT delete this tag too soon.}}&lt;br /&gt;
&lt;br /&gt;
:[Hairbun stands behind a lectern on a podium with two Cueballs and Megan standing behind her. There is a &amp;quot;Grand Opening&amp;quot; sign hanging in the background along with some ornaments.]&lt;br /&gt;
:Hairbun: Our lab will be working on chemistry's top unsolved problems: arbitrary enzyme design, protein folding, depolymerization, and, of course, the biggest one of all:&lt;br /&gt;
:Hairbun: ''Figuring out what the &amp;quot;p&amp;quot; in &amp;quot;pH&amp;quot; stands for.''&lt;br /&gt;
&lt;br /&gt;
{{comic discussion}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Comics featuring Hairbun]]&lt;br /&gt;
[[Category:Comics featuring Cueball]]&lt;br /&gt;
[[Category:Comics featuring Megan]]&lt;br /&gt;
[[Category:Multiple Cueballs]]&lt;br /&gt;
[[Category:Chemistry]]&lt;/div&gt;</summary>
		<author><name>ReadEuler</name></author>	</entry>

	<entry>
		<id>https://www.explainxkcd.com/wiki/index.php?title=2943:_Unsolved_Chemistry_Problems&amp;diff=344002</id>
		<title>2943: Unsolved Chemistry Problems</title>
		<link rel="alternate" type="text/html" href="https://www.explainxkcd.com/wiki/index.php?title=2943:_Unsolved_Chemistry_Problems&amp;diff=344002"/>
				<updated>2024-06-07T19:48:11Z</updated>
		
		<summary type="html">&lt;p&gt;ReadEuler: Add more details about pH&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;{{comic&lt;br /&gt;
| number    = 2943&lt;br /&gt;
| date      = June 7, 2024&lt;br /&gt;
| title     = Unsolved Chemistry Problems&lt;br /&gt;
| image     = unsolved_chemistry_problems_2x.png&lt;br /&gt;
| imagesize = 361x386px&lt;br /&gt;
| noexpand  = true&lt;br /&gt;
| titletext = I'm an H⁺ denier, in that I refuse to consider loose protons to be real hydrogen, so I personally believe it stands for 'pretend'.&lt;br /&gt;
}}&lt;br /&gt;
&lt;br /&gt;
==Explanation==&lt;br /&gt;
{{incomplete|Created by a Loose Proton Called H+ - Please change this comment when editing this page. Do NOT delete this tag too soon.}}&lt;br /&gt;
&lt;br /&gt;
There is a list of mathematical problems that are yet to be solved (such as P=NP). This comic makes a spin on it, by stating that there are (as of yet) unsolved chemistry problems. &lt;br /&gt;
&lt;br /&gt;
Arbitrary Enzyme Design:&lt;br /&gt;
&lt;br /&gt;
Protein Folding: &lt;br /&gt;
&lt;br /&gt;
Depolymerization:&lt;br /&gt;
&lt;br /&gt;
What the “p” in pH stands for:&lt;br /&gt;
&lt;br /&gt;
“p” shows up in pH, pKa, pKb, and other things related to the concentration of H+ ions and OH- ions.  The meaning of the &amp;quot;p&amp;quot; in &amp;quot;pH&amp;quot; has been the subject of much dispute.  It is sometimes referred to as &amp;quot;power of Hydrogen&amp;quot;, but the term was introduced by [Søren Peter Lauritz Sørensen](https://en.wikipedia.org/wiki/S._P._L._S%C3%B8rensen), who did not publish his results in English. The letter p could stand for the French puissance, German Potenz, or Danish potens, all meaning &amp;quot;power&amp;quot;, or it could mean &amp;quot;potential&amp;quot;. All of these words start with the letter p in French, German, and Danish, which were the languages in which Sørensen published.&lt;br /&gt;
&lt;br /&gt;
Someone, presumably Randall Monroe, claims that they refuse to believe that loose protons are hydrogen atoms, and as such, the “p” stands for pretend. This could work, by saying that it is the pretend Ka and the Pretend Kb. However, Hydrogen atoms and loose protons both have a single proton. An Ion is any atom with a number of electrons not equal to the amount of protons in an atom. This counts for both more electrons (Anions), and less electrons (Cations). &lt;br /&gt;
&lt;br /&gt;
==Transcript==&lt;br /&gt;
{{incomplete transcript|Do NOT delete this tag too soon.}}&lt;br /&gt;
&lt;br /&gt;
:[Hairbun stands behind a lectern on a podium with two Cueballs and Megan standing behind her. There is a &amp;quot;Grand Opening&amp;quot; sign hanging in the background along with some ornaments.]&lt;br /&gt;
:Hairbun: Our lab will be working on chemistry's top unsolved problems: arbitrary enzyme design, protein folding, depolymerization, and, of course, the biggest one of all:&lt;br /&gt;
:Hairbun: ''Figuring out what the &amp;quot;p&amp;quot; in &amp;quot;pH&amp;quot; stands for.''&lt;br /&gt;
&lt;br /&gt;
{{comic discussion}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Comics featuring Hairbun]]&lt;br /&gt;
[[Category:Comics featuring Cueball]]&lt;br /&gt;
[[Category:Comics featuring Megan]]&lt;br /&gt;
[[Category:Multiple Cueballs]]&lt;br /&gt;
[[Category:Chemistry]]&lt;/div&gt;</summary>
		<author><name>ReadEuler</name></author>	</entry>

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