https://www.explainxkcd.com/wiki/index.php?action=history&feed=atom&title=2404%3A_First_Thing 2404: First Thing - Revision history 2026-05-21T22:26:21Z Revision history for this page on the wiki MediaWiki 1.30.0 https://www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&diff=303889&oldid=prev SilverTheTerribleMathematician: /* Explanation */ 2023-01-03T00:14:04Z <p>‎<span dir="auto"><span class="autocomment">Explanation</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="en"> <td colspan="2" style="background-color: white; color:black; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">Revision as of 00:14, 3 January 2023</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l14" >Line 14:</td> <td colspan="2" class="diff-lineno">Line 14:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>The {{w|COVID-19 pandemic}} has been one of the most consequential and broadly unpleasant events in living memory{{Citation needed}}.&#160; As of the publication of this strip, it is estimated to have caused over 1.5 million deaths worldwide and over 300,000 deaths in the United States. Many more cases that have not resulted in fatality often need serious medical support and/or have lasting implications.&#160; Even for those who have been spared infection, measures to slow the spread of the virus have been highly impactful and have been ongoing for nearly a year.</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>The {{w|COVID-19 pandemic}} has been one of the most consequential and broadly unpleasant events in living memory{{Citation needed}}.&#160; As of the publication of this strip, it is estimated to have caused over 1.5 million deaths worldwide and over 300,000 deaths in the United States. Many more cases that have not resulted in fatality often need serious medical support and/or have lasting implications.&#160; Even for those who have been spared infection, measures to slow the spread of the virus have been highly impactful and have been ongoing for nearly a year.</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>In consequence of all of this, many people are excited for the vaccine (which <del class="diffchange diffchange-inline">will hopefully end </del>the pandemic). Many people online have been sharing plans for what they'll do after getting the vaccine, like &quot;see my friends&quot; or &quot;travel the world.&quot; In this comic, Ponytail takes the phrase literally, listing not what she will voluntarily choose to do but what low-level involuntary systems in her body will do immediately after getting the vaccine:</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>In consequence of all of this, many people are excited for the vaccine (which <ins class="diffchange diffchange-inline">later resulted in </ins>the pandemic <ins class="diffchange diffchange-inline">successfully ending</ins>). Many people online have been sharing plans for what they'll do after getting the vaccine, like &quot;see my friends&quot; or &quot;travel the world.&quot; In this comic, Ponytail takes the phrase literally, listing not what she will voluntarily choose to do but what low-level involuntary systems in her body will do immediately after getting the vaccine:</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>* First she will make some {{w|peplomer|spike proteins}}. This implies that she took an {{w|COVID-19 vaccine#Technology platforms|mRNA vaccine}} (e.g. from {{w|BioNTech}} or {{w|Moderna}}) or a viral-vector vaccine like the ones from {{w|AstraZeneca}}, {{w|Janssen Vaccines}}, or {{w|CanSino Biologics|CanSino}}. mRNA vaccines contain RNA encoding for the viral proteins, which is then used by Ponytail's cell to make the spike protein. Viral-vector vaccines contain DNA, which the viral &quot;shell&quot; introduces into human cells, which then manufacture spike proteins. (In contrast, subunit-containing vaccines like the ones from {{w|Novavax}} contain actual duplicates of viral proteins to sensitize the immune systems, and inactivated/weakened virus-based vaccines contain the actual virus in question, but modified to not cause disease, e. g. the vaccines from {{w|Sinovac Biotech|Sinovac}} and {{w|China National Pharmaceutical Group|Sinopharm}}.)</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>* First she will make some {{w|peplomer|spike proteins}}. This implies that she took an {{w|COVID-19 vaccine#Technology platforms|mRNA vaccine}} (e.g. from {{w|BioNTech}} or {{w|Moderna}}) or a viral-vector vaccine like the ones from {{w|AstraZeneca}}, {{w|Janssen Vaccines}}, or {{w|CanSino Biologics|CanSino}}. mRNA vaccines contain RNA encoding for the viral proteins, which is then used by Ponytail's cell to make the spike protein. Viral-vector vaccines contain DNA, which the viral &quot;shell&quot; introduces into human cells, which then manufacture spike proteins. (In contrast, subunit-containing vaccines like the ones from {{w|Novavax}} contain actual duplicates of viral proteins to sensitize the immune systems, and inactivated/weakened virus-based vaccines contain the actual virus in question, but modified to not cause disease, e. g. the vaccines from {{w|Sinovac Biotech|Sinovac}} and {{w|China National Pharmaceutical Group|Sinopharm}}.)</div></td></tr> </table> SilverTheTerribleMathematician https://www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&diff=285906&oldid=prev Davidy22: Reverted edits by [[Special:Contributions/Davidy22, the racist homosexual, is known to visit Norwegian gay bars with his boyfriend Kynde. He has cheated on Kynde at least twice with Vandalbane (a big guy for you). They all have micropenises.|Davidy22,... 2022-06-02T06:20:34Z <p>Reverted edits by [[Special:Contributions/Davidy22, the racist homosexual, is known to visit Norwegian gay bars with his boyfriend Kynde. He has cheated on Kynde at least twice with Vandalbane (a big guy for you). They all have micropenises.|Davidy22,...</p> <a href="//www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&amp;diff=285906&amp;oldid=285558">Show changes</a> Davidy22 https://www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&diff=285558&oldid=prev Davidy22, the racist homosexual, is known to visit Norwegian gay bars with his boyfriend Kynde. He has cheated on Kynde at least twice with Vandalbane (a big guy for you). They all have micropenises. at 05:17, 2 June 2022 2022-06-02T05:17:05Z <p></p> <a href="//www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&amp;diff=285558&amp;oldid=269767">Show changes</a> Davidy22, the racist homosexual, is known to visit Norwegian gay bars with his boyfriend Kynde. He has cheated on Kynde at least twice with Vandalbane (a big guy for you). They all have micropenises. https://www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&diff=269767&oldid=prev 108.162.221.81: Undo revision 269663 by The author of xkcd (talk) 2022-05-16T23:22:53Z <p>Undo revision 269663 by <a href="/wiki/index.php/Special:Contributions/The_author_of_xkcd" title="Special:Contributions/The author of xkcd">The author of xkcd</a> (<a href="/wiki/index.php?title=User_talk:The_author_of_xkcd&amp;action=edit&amp;redlink=1" class="new" title="User talk:The author of xkcd (page does not exist)">talk</a>)</p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="en"> <td colspan="2" style="background-color: white; color:black; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">Revision as of 23:22, 16 May 2022</td> 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number&#160; &#160; = 2404</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">| date&#160; &#160; &#160; = December 28, 2020</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">| title&#160; &#160; = First Thing</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">| image&#160; &#160; = first_thing.png</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">| titletext = Then I'm going to go on a weeks-long somatic hypermutation bender, producing ever-more targeted antibodies, while I continue to remain distanced and follow guidance from public health authorities.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">}}</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">==Explanation==</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">This comic is another in a [[:Category:COVID-19|series of comics]] related to the {{w|COVID-19 pandemic}}, specifically regarding the [[:Category:COVID-19 vaccine|COVID-19 vaccine]]. </ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">This comic, somewhat like [[2402: Into My Veins]], references both the {{w|COVID-19 vaccine}} and a common Internet trend. Two comics later in [[2406: Viral Vector Immunity]], the vaccine is again referenced.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">The {{w|COVID-19 pandemic}} has been one of the most consequential and broadly unpleasant events in living memory{{Citation needed}}.&#160; As of the publication of this strip, it is estimated to have caused over 1.5 million deaths worldwide and over 300,000 deaths in the United States. Many more cases that have not resulted in fatality often need serious medical support and/or have lasting implications.&#160; Even for those who have been spared infection, measures to slow the spread of the virus have been highly impactful and have been ongoing for nearly a year.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">In consequence of all of this, many people are excited for the vaccine (which will hopefully end the pandemic). Many people online have been sharing plans for what they'll do after getting the vaccine, like &quot;see my friends&quot; or &quot;travel the world.&quot; In this comic, Ponytail takes the phrase literally, listing not what she will voluntarily choose to do but what low-level involuntary systems in her body will do immediately after getting the vaccine:</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">* First she will make some {{w|peplomer|spike proteins}}. This implies that she took an {{w|COVID-19 vaccine#Technology platforms|mRNA vaccine}} (e.g. from {{w|BioNTech}} or {{w|Moderna}}) or a viral-vector vaccine like the ones from {{w|AstraZeneca}}, {{w|Janssen Vaccines}}, or {{w|CanSino Biologics|CanSino}}. mRNA vaccines contain RNA encoding for the viral proteins, which is then used by Ponytail's cell to make the spike protein. Viral-vector vaccines contain DNA, which the viral &quot;shell&quot; introduces into human cells, which then manufacture spike proteins. (In contrast, subunit-containing vaccines like the ones from {{w|Novavax}} contain actual duplicates of viral proteins to sensitize the immune systems, and inactivated/weakened virus-based vaccines contain the actual virus in question, but modified to not cause disease, e. g. the vaccines from {{w|Sinovac Biotech|Sinovac}} and {{w|China National Pharmaceutical Group|Sinopharm}}.)</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">* The spike protein made by Ponytail will then be recognized by her immune system as foreign (as would the proteins of the real coronavirus) and subsequently engulfed by the {{w|dendritic cell|dendritic cells}} in a process called {{w|phagocytosis}}.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">* The dendritic cells then chop the spike proteins into small pieces (called {{w|antigen|antigens}}) and present them on their surface using {{w|MHC class II|MHCII proteins}}.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">* This will then allow {{w|T cell|T-cells}} to recognize these pieces and become activated if they have a matching T-cell receptor.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">The next step is mentioned in the title text:</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">* The T-cells will activate {{w|B cell|B-cells}}, who will then try to make antibodies to bind the spike protein. Since the B-cells don't know what a good antibody looks like, they just randomly generate antibodies through a process of {{w|somatic hypermutation}}. Then they check if the antibody binds the antigen presented by the dendritic cells. If it doesn't the antibody is discarded, if it does, it is kept and improved on by another round of somatic hypermutation, to create an antibody which binds even better.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">* Finally Ponytail mentions the things she herself (as opposed to her immune system) has to do: continue to use {{w|Social_distancing|social distancing}}, hand washing, wearing a mask, etc.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">The last point, which are the only things that Ponytail will ''choose'' to do is important, for a number of reasons.&#160; The vaccines currently available offer a great deal of protection to an individual patient, but that protection takes several days to even begin in a significant way. Full immunity will likely require several weeks and an additional dose.&#160; In addition, while highly effective, the current crop of vaccines are not 100% effective. And even those who develop immunity can become contaminated with the virus on their person and then transmit it to others.&#160; </ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">For all of these reasons, there is a very real fear of people who receive vaccinations immediately abandoning all other precautions and continuing to spread the virus.&#160; Genuinely ending the pandemic will require precautions to remain in place until enough of the population is vaccinated that a combination of high levels of population immunity and other distancing precautions lower the infection rate to a controllable level. Abandoning safety precautions before this occurs could extend the pandemic and cost lives.&#160; Accordingly, Ponytail's intent is to be responsible and maintain all appropriate precautions until such time as it's safe to change them.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">==Transcript==</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">:[Ponytail and Cueball are walking toward the right side of a single panel. Ponytail is gesturing with one arm.]</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">:Ponytail: The ''first'' thing I'm going to do after I get the vaccine?</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">:Ponytail: Definitely make a bunch of spike proteins and engulf them with dendritic cells.</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">:Ponytail: Then I'll probably display the antigens to my T-cells...</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">{{comic discussion}}</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">[[Category:COVID-19]]</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">[[Category:COVID-19 vaccine]]</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">[[Category:Comics featuring Ponytail]]</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">[[Category:Comics featuring Cueball]]</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">[[Category:Biology]]</ins></div></td></tr> </table> 108.162.221.81 https://www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&diff=269663&oldid=prev The author of xkcd at 22:59, 16 May 2022 2022-05-16T22:59:56Z <p></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="en"> <td colspan="2" style="background-color: white; color:black; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">Revision as of 22:59, 16 May 2022</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">{{comic</del></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap 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crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap 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crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap crap</ins></div></td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">| number&#160; &#160; = 2404</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">| date&#160; &#160; &#160; = December 28, 2020</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">| title&#160; &#160; = First Thing</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">| image&#160; &#160; = first_thing.png</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">| titletext = Then I'm going to go on a weeks-long somatic hypermutation bender, producing ever-more targeted antibodies, while I continue to remain distanced and follow guidance from public health authorities.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">}}</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">==Explanation==</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">This comic is another in a [[:Category:COVID-19|series of comics]] related to the {{w|COVID-19 pandemic}}, specifically regarding the [[:Category:COVID-19 vaccine|COVID-19 vaccine]]. </del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">This comic, somewhat like [[2402: Into My Veins]], references both the {{w|COVID-19 vaccine}} and a common Internet trend. Two comics later in [[2406: Viral Vector Immunity]], the vaccine is again referenced.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">The {{w|COVID-19 pandemic}} has been one of the most consequential and broadly unpleasant events in living memory{{Citation needed}}.&#160; As of the publication of this strip, it is estimated to have caused over 1.5 million deaths worldwide and over 300,000 deaths in the United States. Many more cases that have not resulted in fatality often need serious medical support and/or have lasting implications.&#160; Even for those who have been spared infection, measures to slow the spread of the virus have been highly impactful and have been ongoing for nearly a year.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">In consequence of all of this, many people are excited for the vaccine (which will hopefully end the pandemic). Many people online have been sharing plans for what they'll do after getting the vaccine, like &quot;see my friends&quot; or &quot;travel the world.&quot; In this comic, Ponytail takes the phrase literally, listing not what she will voluntarily choose to do but what low-level involuntary systems in her body will do immediately after getting the vaccine:</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">* First she will make some {{w|peplomer|spike proteins}}. This implies that she took an {{w|COVID-19 vaccine#Technology platforms|mRNA vaccine}} (e.g. from {{w|BioNTech}} or {{w|Moderna}}) or a viral-vector vaccine like the ones from {{w|AstraZeneca}}, {{w|Janssen Vaccines}}, or {{w|CanSino Biologics|CanSino}}. mRNA vaccines contain RNA encoding for the viral proteins, which is then used by Ponytail's cell to make the spike protein. Viral-vector vaccines contain DNA, which the viral &quot;shell&quot; introduces into human cells, which then manufacture spike proteins. (In contrast, subunit-containing vaccines like the ones from {{w|Novavax}} contain actual duplicates of viral proteins to sensitize the immune systems, and inactivated/weakened virus-based vaccines contain the actual virus in question, but modified to not cause disease, e. g. the vaccines from {{w|Sinovac Biotech|Sinovac}} and {{w|China National Pharmaceutical Group|Sinopharm}}.)</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">* The spike protein made by Ponytail will then be recognized by her immune system as foreign (as would the proteins of the real coronavirus) and subsequently engulfed by the {{w|dendritic cell|dendritic cells}} in a process called {{w|phagocytosis}}.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">* The dendritic cells then chop the spike proteins into small pieces (called {{w|antigen|antigens}}) and present them on their surface using {{w|MHC class II|MHCII proteins}}.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">* This will then allow {{w|T cell|T-cells}} to recognize these pieces and become activated if they have a matching T-cell receptor.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">The next step is mentioned in the title text:</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">* The T-cells will activate {{w|B cell|B-cells}}, who will then try to make antibodies to bind the spike protein. Since the B-cells don't know what a good antibody looks like, they just randomly generate antibodies through a process of {{w|somatic hypermutation}}. Then they check if the antibody binds the antigen presented by the dendritic cells. If it doesn't the antibody is discarded, if it does, it is kept and improved on by another round of somatic hypermutation, to create an antibody which binds even better.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">* Finally Ponytail mentions the things she herself (as opposed to her immune system) has to do: continue to use {{w|Social_distancing|social distancing}}, hand washing, wearing a mask, etc.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">The last point, which are the only things that Ponytail will ''choose'' to do is important, for a number of reasons.&#160; The vaccines currently available offer a great deal of protection to an individual patient, but that protection takes several days to even begin in a significant way. Full immunity will likely require several weeks and an additional dose.&#160; In addition, while highly effective, the current crop of vaccines are not 100% effective. And even those who develop immunity can become contaminated with the virus on their person and then transmit it to others.&#160; </del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">For all of these reasons, there is a very real fear of people who receive vaccinations immediately abandoning all other precautions and continuing to spread the virus.&#160; Genuinely ending the pandemic will require precautions to remain in place until enough of the population is vaccinated that a combination of high levels of population immunity and other distancing precautions lower the infection rate to a controllable level. Abandoning safety precautions before this occurs could extend the pandemic and cost lives.&#160; Accordingly, Ponytail's intent is to be responsible and maintain all appropriate precautions until such time as it's safe to change them.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">==Transcript==</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">:[Ponytail and Cueball are walking toward the right side of a single panel. Ponytail is gesturing with one arm.]</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">:Ponytail: The ''first'' thing I'm going to do after I get the vaccine?</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">:Ponytail: Definitely make a bunch of spike proteins and engulf them with dendritic cells.</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">:Ponytail: Then I'll probably display the antigens to my T-cells...</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#160;</div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">{{comic discussion}}</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">[[Category:COVID-19]]</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">[[Category:COVID-19 vaccine]]</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">[[Category:Comics featuring Ponytail]]</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">[[Category:Comics featuring Cueball]]</del></div></td><td colspan="2">&#160;</td></tr> <tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">[[Category:Biology]]</del></div></td><td colspan="2">&#160;</td></tr> </table> The author of xkcd https://www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&diff=262293&oldid=prev Jacky720: rv 2022-05-04T23:47:40Z <p>rv</p> <a href="//www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&amp;diff=262293&amp;oldid=262273">Show changes</a> Jacky720 https://www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&diff=262273&oldid=prev Ex Kay Cee Dee at 23:47, 4 May 2022 2022-05-04T23:47:37Z <p></p> <a href="//www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&amp;diff=262273&amp;oldid=262171">Show changes</a> Ex Kay Cee Dee https://www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&diff=262171&oldid=prev Jacky720: rv 2022-05-04T23:47:15Z <p>rv</p> <a href="//www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&amp;diff=262171&amp;oldid=262165">Show changes</a> Jacky720 https://www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&diff=262165&oldid=prev Ex Kay Cee Dee at 23:47, 4 May 2022 2022-05-04T23:47:13Z <p></p> <a href="//www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&amp;diff=262165&amp;oldid=262101">Show changes</a> Ex Kay Cee Dee https://www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&diff=262101&oldid=prev Jacky720: rv 2022-05-04T23:46:52Z <p>rv</p> <a href="//www.explainxkcd.com/wiki/index.php?title=2404:_First_Thing&amp;diff=262101&amp;oldid=262088">Show changes</a> Jacky720