2425: mRNA Vaccine - Revision history

DKMell: minor

2025-02-27T23:05:20Z

minor

DollarStoreBa'al at 16:08, 27 February 2025

2025-02-27T16:08:59Z

DollarStoreBa'al at 16:08, 27 February 2025

2025-02-27T16:08:30Z

DollarStoreBa'al at 16:07, 27 February 2025

2025-02-27T16:07:15Z

172.68.205.122: Undo revision 360010 by 172.71.215.179 (talk) No. Excluded as a multi-panel comic.

2024-12-21T14:05:17Z

Undo revision 360010 by 172.71.215.179 (talk) No. Excluded as a multi-panel comic.

172.71.215.179 at 03:29, 21 December 2024

2024-12-21T03:29:13Z

172.69.43.182: Category says: "Note: this category is for large singular images, not for long comics that contain a large number of panels."

2024-11-23T09:14:49Z

Category says: "Note: this category is for large singular images, not for long comics that contain a large number of panels."

172.71.218.2 at 03:32, 23 November 2024

2024-11-23T03:32:48Z

42.book.addict at 20:54, 5 September 2024

2024-09-05T20:54:23Z

172.69.134.222: /* Explanation */

2024-07-25T04:55:33Z

‎Explanation

@@ Line 31: / Line 31: @@
 References to the ''{{w|Star Wars}}'' franchise are a [[:Category:Star Wars|recurring theme]] on xkcd.
-RNA would also make an appearance in [[3002: RNAWorld]] and [[3056: RNA]]
+RNA would also make an appearance in [[3002: RNAWorld]] and [[3056: RNA]].
 ==Transcript==

@@ Line 31: / Line 31: @@
 References to the ''{{w|Star Wars}}'' franchise are a [[:Category:Star Wars|recurring theme]] on xkcd.
-RNA would also make an appearance in [[3002: RNAWorld]] and [[3056:RNA]]
+RNA would also make an appearance in [[3002: RNAWorld]] and [[3056: RNA]]
 ==Transcript==

@@ Line 31: / Line 31: @@
 References to the ''{{w|Star Wars}}'' franchise are a [[:Category:Star Wars|recurring theme]] on xkcd.
-RNA would also make an appearance in [[3002]] and [[3056]]
+RNA would also make an appearance in [[3002: RNAWorld]] and [[3056:RNA]]
 ==Transcript==

← Older revision		Revision as of 16:07, 27 February 2025
Line 30:		Line 30:

	References to the ''{{w\|Star Wars}}'' franchise are a [[:Category:Star Wars\|recurring theme]] on xkcd.		References to the ''{{w\|Star Wars}}'' franchise are a [[:Category:Star Wars\|recurring theme]] on xkcd.
		+
		+	RNA would also make an appearance in [[3002]] and [[3056]]

	==Transcript==		==Transcript==

← Older revision		Revision as of 14:05, 21 December 2024
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	[[Category:Star Wars]]		[[Category:Star Wars]]
	[[Category:Biology]]		[[Category:Biology]]
−	~~[[Category:Large drawings]]~~

← Older revision		Revision as of 03:29, 21 December 2024
Line 173:		Line 173:
	[[Category:Star Wars]]		[[Category:Star Wars]]
	[[Category:Biology]]		[[Category:Biology]]
		+	[[Category:Large drawings]]

← Older revision		Revision as of 09:14, 23 November 2024
Line 173:		Line 173:
	[[Category:Star Wars]]		[[Category:Star Wars]]
	[[Category:Biology]]		[[Category:Biology]]
−	~~[[Category:Large drawings]]~~

← Older revision		Revision as of 03:32, 23 November 2024
Line 173:		Line 173:
	[[Category:Star Wars]]		[[Category:Star Wars]]
	[[Category:Biology]]		[[Category:Biology]]
		+	[[Category:Large drawings]]

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 The analogy starts in the second panel, where the Rebel Alliance has retrieved the {{w|Death Star}} plans, conveyed by {{w|Princess Leia}} to General [https://starwars.fandom.com/wiki/Jan_Dodonna Jan Dodonna] (in ''Star Wars'', via {{w|R2-D2}} and some adventures, but shown as a simple handoff here). The Death Star is a space station the size of a small moon that has the power to destroy planets. In the film, the plans are analyzed to find a weakness in the enemy Death Star and destroy it; however, in this panel, the "Death Star plans" are passed down a line of people until they are interpreted as a construction assignment and are used to build a Death Star. In the analogy, the mRNA in the vaccine corresponds to the plans for the Death Star, the spike proteins (inactive COVID-19 virus fragments) correspond to the benign Death Star itself, and the cellular processes that build spike proteins correspond to the builders of the benign Death Star.  Just as merely having the plans on hand led to the Death Star being built, the mere presence of the mRNA in the cellular environment leads to it being translated, producing the viral protein.  Amusingly, as the plans are handed off to the construction crew leader, he replies "Copy that," which is normally just a slang term for "I understand" but here is also a pun that presages his actions.
-After Leia's Death Star has been built, it is positioned near a planet/moon. This Death Star is ''benign'': it only ''looks'' dangerous and isn't about to actually hurt anyone; the Death Star crew are Rebels, after all, and state that they don't have the laser wired up. The Rebels mobilize to destroy this benign Death Star because it looks like an enemy battle station, evidently not listening to the construction crew's transmissions. Analogously, immune cells cannot think {{Citation needed}} or directly communicate, basing their determination of friend from foe entirely on external chemical signatures. However, the Death Star operators are confused, because they believe Leia (a member of the Rebels) had ordered its construction. The Rebels initially attack the surface of the benign Death Star, without much effect; Leia orders the factories to continue developing torpedoes and ships as they run out, presumably putting an extra workload on the factory workers and tiring them out, or at least diverting resources away from other projects. In the analogy, the Rebels correspond to the immune system's {{w|B cells}} and {{w|T cells}}, which mobilize to attack the spike proteins (the benign Death Star) made as a result of the vaccine, but are often ineffective at first. The body keeps producing these immune cells, trying many variants (many ways of attacking the benign Death Star) in an attempt to find one that works well against the spike proteins. This results in Cueball experiencing {{w|side effects}} from the vaccine, including soreness and tiredness, and he lies down and rests.
+After Leia's Death Star has been built, it is positioned near a planet/moon. This Death Star is ''benign'': it only ''looks'' dangerous and isn't about to actually hurt anyone; the Death Star crew are Rebels, after all, and state that they don't have the laser wired up. The Rebels mobilize to destroy this benign Death Star because it looks like an enemy battle station, evidently not listening to the construction crew's transmissions. Analogously, immune cells cannot think{{Citation needed}} or directly communicate, basing their determination of friend from foe entirely on external chemical signatures. However, the Death Star operators are confused, because they believe Leia (a member of the Rebels) had ordered its construction. The Rebels initially attack the surface of the benign Death Star, without much effect; Leia orders the factories to continue developing torpedoes and ships as they run out, presumably putting an extra workload on the factory workers and tiring them out, or at least diverting resources away from other projects. In the analogy, the Rebels correspond to the immune system's {{w|B cells}} and {{w|T cells}}, which mobilize to attack the spike proteins (the benign Death Star) made as a result of the vaccine, but are often ineffective at first. The body keeps producing these immune cells, trying many variants (many ways of attacking the benign Death Star) in an attempt to find one that works well against the spike proteins. This results in Cueball experiencing {{w|side effects}} from the vaccine, including soreness and tiredness, and he lies down and rests.
 After much effort on the Rebels' part, they find a weakness in the benign Death Star, a "thermal exhaust port" vulnerable to "proton torpedoes" that can destroy the Death Star. Firing a proton torpedo down the exhaust port destroys a Death Star very rapidly, compared to the initial, ineffective frontal assault on the surface. After this benign Death Star is destroyed, Princess Leia allows the fleet to stand down.

@@ Line 13: / Line 13: @@
 This one is another analogy to how {{w|mRNA vaccines}} work, by creating inactive fragments of the virus to prime the immune system to be prepared to stave off the real thing. This is done in response to Cueball's question to the person vaccinating him, "Why would my body attack something it made itself?", using elements of the film ''{{w|Star Wars (film)|Star Wars: Episode IV}}'' as an analogy.
-The analogy starts in the second panel, where the Rebel Alliance has retrieved the {{w|Death Star}} plans, conveyed by {{w|Princess Leia}} to General [https://starwars.fandom.com/wiki/Jan_Dodonna Jan Dodonna] (in ''Star Wars'', via {{w|R2-D2}} and some adventures, but shown as a simple handoff here). The Death Star is a space station the size of a small moon that has the power to destroy planets. In the film, the plans are analyzed to find a weakness in the enemy Death Star and destroy it; however, in this panel, the "Death Star plans" are passed down a line of people until they are interpreted as a construction assignment and are used to build a Death Star. In the analogy, the mRNA in the vaccine corresponds to the plans for the Death Star, the spike proteins (inactive COVID-19 virus fragments) correspond to the benign Death Star itself, and the cellular processes that build spike proteins correspond to the builders of the benign Death Star.  Just as merely having the plans on hand led to the Death Star being built, the mere presence of the mRNA in the cellular environment leads to it being translated, producing the viral protein.  Amusingly, as the plans are handed off to the construction crew leader, he replies "Copy that," which both acknowledges the handoff in conversation and presages his actions.
+The analogy starts in the second panel, where the Rebel Alliance has retrieved the {{w|Death Star}} plans, conveyed by {{w|Princess Leia}} to General [https://starwars.fandom.com/wiki/Jan_Dodonna Jan Dodonna] (in ''Star Wars'', via {{w|R2-D2}} and some adventures, but shown as a simple handoff here). The Death Star is a space station the size of a small moon that has the power to destroy planets. In the film, the plans are analyzed to find a weakness in the enemy Death Star and destroy it; however, in this panel, the "Death Star plans" are passed down a line of people until they are interpreted as a construction assignment and are used to build a Death Star. In the analogy, the mRNA in the vaccine corresponds to the plans for the Death Star, the spike proteins (inactive COVID-19 virus fragments) correspond to the benign Death Star itself, and the cellular processes that build spike proteins correspond to the builders of the benign Death Star.  Just as merely having the plans on hand led to the Death Star being built, the mere presence of the mRNA in the cellular environment leads to it being translated, producing the viral protein.  Amusingly, as the plans are handed off to the construction crew leader, he replies "Copy that," which is normally just a slang term for "I understand" but here is also a pun that presages his actions.
 After Leia's Death Star has been built, it is positioned near a planet/moon. This Death Star is ''benign'': it only ''looks'' dangerous and isn't about to actually hurt anyone; the Death Star crew are Rebels, after all, and state that they don't have the laser wired up. The Rebels mobilize to destroy this benign Death Star because it looks like an enemy battle station, evidently not listening to the construction crew's transmissions. Analogously, immune cells cannot think {{Citation needed}} or directly communicate, basing their determination of friend from foe entirely on external chemical signatures. However, the Death Star operators are confused, because they believe Leia (a member of the Rebels) had ordered its construction. The Rebels initially attack the surface of the benign Death Star, without much effect; Leia orders the factories to continue developing torpedoes and ships as they run out, presumably putting an extra workload on the factory workers and tiring them out, or at least diverting resources away from other projects. In the analogy, the Rebels correspond to the immune system's {{w|B cells}} and {{w|T cells}}, which mobilize to attack the spike proteins (the benign Death Star) made as a result of the vaccine, but are often ineffective at first. The body keeps producing these immune cells, trying many variants (many ways of attacking the benign Death Star) in an attempt to find one that works well against the spike proteins. This results in Cueball experiencing {{w|side effects}} from the vaccine, including soreness and tiredness, and he lies down and rests.