938: T-Cells - Revision history

208.69.133.66 at 17:30, 27 January 2026

2026-01-27T17:30:20Z

172.70.42.245: added the wikipedia page for leukocytosis in case people don’t know what that is

2023-07-18T16:31:26Z

added the wikipedia page for leukocytosis in case people don’t know what that is

Natg19: /* Transcript */

2022-08-09T01:57:54Z

‎Transcript

Theusaf: Reverted edits by Donald Trump (talk) to last revision by CRLF

2022-05-26T19:57:37Z

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2022-05-26T19:04:33Z

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2022-05-26T17:49:58Z

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2022-05-26T17:24:21Z

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Xray Kilo Charlie Delta: haha your js cant stop my js

2022-05-23T18:20:50Z

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Theusaf: Reverted edits by 👖🔥 (talk) to last revision by Jacky720

2022-05-11T18:46:16Z

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 Cueball possibly could have guessed this because he is familiar with biology according to this comic and one of the most common diseases that attacks T-cells would be HIV.
-Although highly expensive (because it currently requires customized set of alterations for each individual cancer), over the next few years subsequent clinical trials revealed the power of these super-strong T-cells (called Chimeric Antigen Receptor T-cells, or CAR T-cells for short) to cure previously uncurable cancers.  For example, in 75 children with previously untreatable leukemia, 4 in 5 had no detectable cancer three months after treatment with CAR T-cells ([https://www.nejm.org/doi/full/10.1056/NEJMoa1709866 Maude et al. NEJM 2013]). More and more different kinds of CAR T-cells are becoming FDA approved to treat a growing number of cancers. Seven years after this cartoon, the American Society of Clinical Oncology chose CAR T-cells as the [https://www.cancer.net/blog/2018-01/car-t-cell-immunotherapy-2018-advance-year 2018 Advance of the Year].
+Over the next few years after this comic was published, subsequent clinical trials revealed the power of these super-strong T-cells (called Chimeric Antigen Receptor T-cells, or CAR T-cells for short) to cure previously uncurable cancers.  For example, in 75 children with previously untreatable leukemia, 4 in 5 had no detectable cancer three months after treatment with CAR T-cells ([https://www.nejm.org/doi/full/10.1056/NEJMoa1709866 Maude et al. NEJM 2013]). More and more different kinds of CAR T-cells are becoming FDA approved to treat a growing number of cancers. Seven years after this cartoon, the American Society of Clinical Oncology chose CAR T-cells as the [https://www.cancer.net/blog/2018-01/car-t-cell-immunotherapy-2018-advance-year 2018 Advance of the Year].
 ==Transcript==

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 In this case, the two characters are talking about a trial in which immune cells are taken out of the patient's body and genetically modified. The modified cells are able to both attack the cancer cells and replicate very quickly. However, to make these genetic changes inside the cells, they used {{w|HIV}} as the vehicle to introduce these new genes as it is specialized in invading and modifying immune cells.  HIV is good for this because HIV attacks your T-cells and slowly kills off your immune system. If HIV was used as a {{w|vector (molecular biology)|vector}} to introduce a trait into your T-cells it could express a trait to hunt tumors and since it is already good at changing your T-cells it would be well-suited to this task.
-Basically, this treatment seems to replace one terrible disease with another terrible disease. As the title text says, they don't know how to get rid of the modified T-cells after they remove the cancer. And the last part of the title text is a joke, in which the doctor suggests yet another disease, {{w|smallpox}}, to inject into the patient's body.  This is similar to the song {{w|There Was an Old Lady Who Swallowed a Fly}} in which a little old lady who swallowed a fly where each time she puts some other animal in her body to get rid of the last one and eventually she dies.  This is akin to that as you have cancer so you put super-strong T-cells modified by HIV to get rid of them but then you have Leukocytosis so you get smallpox to kill those, and so on.
+Basically, this treatment seems to replace one terrible disease with another terrible disease. As the title text says, they don't know how to get rid of the modified T-cells after they remove the cancer. And the last part of the title text is a joke, in which the doctor suggests yet another disease, {{w|smallpox}}, to inject into the patient's body.  This is similar to the song {{w|There Was an Old Lady Who Swallowed a Fly}} in which a little old lady who swallowed a fly where each time she puts some other animal in her body to get rid of the last one and eventually she dies.  This is akin to that as you have cancer so you put super-strong T-cells modified by HIV to get rid of them but then you have {{w|Leukocytosis}} so you get smallpox to kill those, and so on.
 Cueball possibly could have guessed this because he is familiar with biology according to this comic and one of the most common diseases that attacks T-cells would be HIV.

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