Editing 2404: First Thing

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In consequence of all of this, many people are excited for the vaccine (which later resulted in the pandemic successfully ending). Many people online have been sharing plans for what they'll do after getting the vaccine, like "see my friends" or "travel the world." In this comic, Ponytail takes the phrase literally, listing not what she will voluntarily choose to do but what low-level involuntary systems in her body will do immediately after getting the vaccine:
 
In consequence of all of this, many people are excited for the vaccine (which later resulted in the pandemic successfully ending). Many people online have been sharing plans for what they'll do after getting the vaccine, like "see my friends" or "travel the world." In this comic, Ponytail takes the phrase literally, listing not what she will voluntarily choose to do but what low-level involuntary systems in her body will do immediately after getting the vaccine:
  
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* First she will make some {{w|peplomer|spike proteins}}. This implies that she took an {{w|COVID-19 vaccine#Technology platforms|mRNA vaccine}} (e.g. from {{w|BioNTech}} or {{w|Moderna}}) or a viral-vector vaccine like the ones from {{w|AstraZeneca}}, {{w|Janssen Vaccines}}, or {{w|CanSino Biologics|CanSino}}. mRNA vaccines contain RNA encoding for the viral proteins, which is then used by Ponytail's cell to make the spike protein. Viral-vector vaccines contain DNA, which the viral "shell" introduces into human cells, which then manufacture spike proteins. (In contrast, subunit-containing vaccines like the ones from {{w|Novavax}} contain actual duplicates of viral proteins to sensitize the immune systems, and inactivated/weakened virus-based vaccines contain the actual virus in question, but modified to not cause disease, e. g. the vaccines from {{w|Sinovac Biotech|Sinovac}} and {{w|China National Pharmaceutical Group|Sinopharm}}.)
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* First she will make some {{w|peplomer|spike proteins}}. This implies that she took an {{w|COVID-19 vaccine#Technology platforms|mRNA vaccine}} (e.g. from {{w|BioNTech}} or {{w|Moderna}}) or a viral-vector vaccine like the ones from {{w|AstraZeneca}} or {{w|CanSino Biologics|CanSino}}. mRNA vaccines contain RNA encoding for the viral proteins, which is then used by Ponytail's cell to make the spike protein. Viral-vector vaccines contain DNA, which the viral "shell" introduces into human cells, which then manufacture spike proteins. (In contrast, subunit-containing vaccines like the ones from {{w|Novavax}} contain actual duplicates of viral proteins to sensitize the immune systems, and inactivated/weakened virus-based vaccines contain the actual virus in question, but modified to not cause disease, e. g. the vaccines from {{w|Sinovac Biotech|Sinovac}} and {{w|China National Pharmaceutical Group|Sinopharm}}.)
 
* The spike protein made by Ponytail will then be recognized by her immune system as foreign (as would the proteins of the real coronavirus) and subsequently engulfed by the {{w|dendritic cell|dendritic cells}} in a process called {{w|phagocytosis}}.
 
* The spike protein made by Ponytail will then be recognized by her immune system as foreign (as would the proteins of the real coronavirus) and subsequently engulfed by the {{w|dendritic cell|dendritic cells}} in a process called {{w|phagocytosis}}.
 
* The dendritic cells then chop the spike proteins into small pieces (called {{w|antigen|antigens}}) and present them on their surface using {{w|MHC class II|MHCII proteins}}.
 
* The dendritic cells then chop the spike proteins into small pieces (called {{w|antigen|antigens}}) and present them on their surface using {{w|MHC class II|MHCII proteins}}.

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