Editing Talk:2652: Proxy Variable
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Might be tangentially related to the alleged Alzheimer's disease drug Aduhelm, the anti-amyloid therapy, that did show some success in proxy variable (biomarker), but no success at all in curing the disease or its symptoms (no efficacy), but which got accepted with a huge amount of controversy by NDA (which disregarded its advisory committee’s recommendation against approving Aduhelm). --[[User:JakubNarebski|JakubNarebski]] ([[User talk:JakubNarebski|talk]]) 07:32, 30 July 2022 (UTC) | Might be tangentially related to the alleged Alzheimer's disease drug Aduhelm, the anti-amyloid therapy, that did show some success in proxy variable (biomarker), but no success at all in curing the disease or its symptoms (no efficacy), but which got accepted with a huge amount of controversy by NDA (which disregarded its advisory committee’s recommendation against approving Aduhelm). --[[User:JakubNarebski|JakubNarebski]] ([[User talk:JakubNarebski|talk]]) 07:32, 30 July 2022 (UTC) | ||
: More relevantly, it came out recently that [https://www.dailykos.com/stories/2022/7/22/2111914/-Two-decades-of-Alzheimer-s-research-may-be-based-on-deliberate-fraud-that-has-cost-millions-of-lives|the last ~decade and a half of Alzheimer's drug research] is based on monitoring effects in mice on a specific biomarker that ''may not actually exist in humans'', and the initial study was potentially fraudulent. Seems like a damn topical proxy variable to me. [[Special:Contributions/162.158.166.249|162.158.166.249]] 00:56, 31 July 2022 (UTC) | : More relevantly, it came out recently that [https://www.dailykos.com/stories/2022/7/22/2111914/-Two-decades-of-Alzheimer-s-research-may-be-based-on-deliberate-fraud-that-has-cost-millions-of-lives|the last ~decade and a half of Alzheimer's drug research] is based on monitoring effects in mice on a specific biomarker that ''may not actually exist in humans'', and the initial study was potentially fraudulent. Seems like a damn topical proxy variable to me. [[Special:Contributions/162.158.166.249|162.158.166.249]] 00:56, 31 July 2022 (UTC) | ||
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