Editing 2406: Viral Vector Immunity
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A viral vector vaccine, also known as a live vector vaccine, uses a modified virus, different from the pathogen being immunized against, as a carrier to deliver a molecular payload into the host body. This modified virus is called the vector because it is the method of delivery of a piece of the pathogen's genetic code. If the recipient has a strong immune response to the vector itself (i.e., the proteins making up the surface of the vector virus), the immunization may be less effective because the vector virus, and hence its payload of viral genetic material, will be destroyed before they can enter the host's cells. It is to some degree a dice roll, with regard to whether some recipients will already be immune to a vector. | A viral vector vaccine, also known as a live vector vaccine, uses a modified virus, different from the pathogen being immunized against, as a carrier to deliver a molecular payload into the host body. This modified virus is called the vector because it is the method of delivery of a piece of the pathogen's genetic code. If the recipient has a strong immune response to the vector itself (i.e., the proteins making up the surface of the vector virus), the immunization may be less effective because the vector virus, and hence its payload of viral genetic material, will be destroyed before they can enter the host's cells. It is to some degree a dice roll, with regard to whether some recipients will already be immune to a vector. | ||
| β | For example, a modified (to be harmless) cold virus can be used to deliver genetic material (RNA or DNA) of another virus into the patient's cells. The cells are induced to manufacture protein found in the pathogenic protein, which the patient's immune system detects and reacts to. That way the immune system recognizes the pathogenic virus without actually being infected with it, which decreases the time needed to react to a real infection. Any patients whose immune systems recognize the modified cold virus | + | For example, a modified (to be harmless) cold virus can be used to deliver genetic material (RNA or DNA) of another virus into the patient's cells. The cells are induced to manufacture protein found in the pathogenic protein, which the patient's immune system detects and reacts to. That way the immune system recognizes the pathogenic virus without actually being infected with it, which decreases the time needed to react to a real infection. Any patients whose immune systems recognize the modified cold virus, and destroy it rapidly, won't get the full intended benefit of creating a strong immune response to the second virus. |
The comic represents this idea with the Trojan horse being the vector, carrying a payload of Greek soldiers into the cell, as represented by the City of Troy. In the original Trojan Horse story, Greek soldiers hid inside a statue of a horse which the Trojans were told was a gift to Athena; the Trojans brought it within their walls (which the Greek army had failed to penetrate in an extended siege), allowing the soldiers in the horse to undermine the city's defenses and let in the rest of their army to take the city. Note: In a viral vector vaccine, the payload inside the vector works to the benefit of the person receiving the vaccine - opposite to the soldiers inside the Trojan horse, who had only malice in mind for the city receiving the "gift" horse. | The comic represents this idea with the Trojan horse being the vector, carrying a payload of Greek soldiers into the cell, as represented by the City of Troy. In the original Trojan Horse story, Greek soldiers hid inside a statue of a horse which the Trojans were told was a gift to Athena; the Trojans brought it within their walls (which the Greek army had failed to penetrate in an extended siege), allowing the soldiers in the horse to undermine the city's defenses and let in the rest of their army to take the city. Note: In a viral vector vaccine, the payload inside the vector works to the benefit of the person receiving the vaccine - opposite to the soldiers inside the Trojan horse, who had only malice in mind for the city receiving the "gift" horse. | ||
