Editing 2422: Vaccine Ordering

{{comic
| number    = 2422
| date      = February 8, 2021
| title     = Vaccine Ordering
| image     = Vaccine_ordering_-_high-resolution.png
| titletext = You know what they say: mRNA-1273 before tozinameran, you'll have to slay a banshee in a catamaran.
}}

==Explanation==
{{incomplete|Created by the RULER OF SMYRNA. Please mention here why this explanation isn't complete. Do NOT delete this tag too soon.}}

Megan is reading an article on her phone to Cueball. A report from the {{w|Centers for Disease Control and Prevention|CDC}} says that it's possible to get effective immunity against {{w|COVID-19}} when taking two-dose {{w|RNA vaccine|mRNA vaccine shots}} successively from pharmaceutical companies Pfizer and Moderna, but that this practice should not be the norm. The report in question can be viewed [https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.html here]; it stresses that mixing the vaccines is acceptable only in exceptional circumstances, such as "when the first-dose vaccine product cannot be determined."

Cueball wonders whether the order in which you receive the vaccines matters. Megan then attempts to create {{w|Mnemonic|mnemonic devices}} to help them remember which mix-and-match strategy is best for the mRNA vaccines (e.g., "Beer before wine and you'll feel fine; wine before beer and you'll feel queer"). Megan succeeds by rhyming "Pfizer" and "wiser", but struggles with finding a rhyme for "Moderna", settling for {{w|Smyrna}}, an ancient city located in what is now {{w|Izmir}}, Turkey.

A {{w|side effect}} of a drug is an effect incidental to the intended purpose of the drug. Side effects can be positive or negative, though in vaccine trials the greater concern is usually about negative side effects. Becoming ruler of an ancient city that is now only a historical ruin would certainly be an odd side effect.

The title text continues the theme of difficult rhymes, using the full names of both the Moderna vaccine drug ({{w|Moderna COVID-19 vaccine|mRNA-1273}}) and the Pfizer one ({{w|Pfizer–BioNTech COVID-19 vaccine|tozinameran}}).

Note: Studies have shown that the order that you have alcoholic drinks doesn't affect the severity of the hangover. The efficacy of mixing vaccines is presently unknown, an important reason why mixing them is discouraged.

==Trivia==

This comic image was originally published with no {{w|Spatial anti-aliasing|anti-aliasing}}. All of its pixels were either fully black or fully white, with no shades of gray, giving the smooth lines a jagged appearance. This was fixed later in the day.

==Transcript==
:[Megan and Cueball are talking. Megan is looking down and reading a news story on her phone.]
:Megan: The CDC says it's okay to mix and match the mRNA vaccines for doses 1 and 2, but only in exceptional circumstances.
:Cueball: I wonder which order works better, if either.

:[A slimmer panel. Megan has her finger raised and her phone to her side]
Megan: Well you know what they say — Moderna before Pfizer, you'll be none the wiser. 

:[A regular panel, Megan and Cueball still talking next to each other.]
:Megan: Pfizer before Moderna then you'll... rule ancient Smyrna.
:Cueball: Weird side effect.
:Megan: A lot of hard-to-rhyme drugs have those.

{{comic discussion}}
[[Category:COVID-19]]
[[Category:Language]]
[[Category:Comics featuring Cueball]]
[[Category:Comics featuring Megan]]